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This Service

A database built with INDRA combining content from numerous readers and databases. This page allows you to curate the loaded statements. For more information please see the manual.

This Project

INDRA is developed by indralabs, a part of the Harvard Medical School Laboratory of Systems Pharmacology.

This project, indra_db, is also developed by the indralab team. For more information on how we procure our sources, you can go here. This work was funded by ARO grant W911NF‐15‐1‐0544 under the DARPA Communicating with Computers program.

IndraLab

Statements

RAS binds SOS1, GRB2, and PDGFRB. 1 / 1

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"RasGAP binding to phospho-PDGFRβ causes simultaneous binding of the Grb2-SOS1 complex to Ras that offsets the activation of Ras and reduces the downstream activity of the extracellular signal-regulated protein kinases 1 and 2 (Erk1/2), as shown in vitro xref ."

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Our Sources:

INDRA allows us to combine the results from a multitude of sources. In particular, the INDRA Database draws on the following...