IndraLab

Statements

TNF activates SCN10A. 12 / 12
1 | 1 10
signor
"TNF-α increases Na(+) currents by accelerating the channel activation as well as increasing the expression of VGSCs in a mechanism dependent upon NF-κB and p38 MAPK signal pathways in CNS neurons. TNF-α increased Na(+) currents by accelerating the activation of VGSCs. The threshold for action potential (AP) was decreased and firing rate were increased. VGSCs were up-regulated at both the mRNA and protein levels."
26112872
reach
"Indeed, recombinant rat TNF (rrTNF) enhanced the current densities of TTX-S and Nav1.8 in cultured DRG neurons dose-dependently."
21145890
reach
"Furthermore, inhibition of TNF-α synthesis, which prevented neuropathic pain, strongly inhibited the up-regulation of Nav1.3 and Nav1.8."
20638792
reach
"Moreover, TNF-α was reported to induce Nav1.8 upregulation in uninjured sciatic nerve fibers following L5 ventral root transection (L5-VRT) [66]."
32489585
reach
"TNF-α mediated increase in Nav1.8 current density increases neuronal excitability, likely contributing to increased mechanical allodynia following motor nerve injury (Chen et al., 2011)."
22007172
reach
"In particular, TNF-α and IL-1β have been shown to increase the sensitivity and excitability of sensory neurons by activating the TTX-resistant sodium channels Nav1.8 [16, 17]."
19523695
eidos
"Moreover , TNF-alpha was reported to induce Nav1.8 upregulation in uninjured sciatic nerve fibers following L5 ventral root transection ( L5-VRT ) [ 66 ] ."
32489585
reach
"Interestingly, both Nav 1.3 and Nav 1.8 up-regulation was mediated by cytokine TNFα, as was shown by inhibition of TNFα synthesis [26,38]."
22189061
reach
"Inhibition of TNF-α synthesis blocks the upregulation of Nav1.8 and prevents the development of neuropathic pain [66]."
32489585
reach
"For example, IL-1β could activate voltage-gated calcium channels and inhibit voltage-gated sodium channels, while TNF-α could up-regulate voltage-gated sodium channels (NAV1.3 and NAV1.8) and increase sodium influx."
35089644
reach
"A previous study demonstrated that TNF-α increased the current densities of Nav1.8 in DRG neurons (Chen et al., 2011)."
30374312
reach
"These data suggest that increased TNF-α may be responsible for up-regulation of Nav1.3 and Nav1.8 in uninjured DRG neurons following nerve injury."
20638792