IndraLab

Statements

BAP1 increases the amount of PTGS2. 9 / 9
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"Gene and protein expression of both COX-2 and mPGES-1 are induced by BaP1 via activation of distinct subunits of the NF-κB transcription factor."
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"Partially consistent with our results, BAP1 was unfolded to increase the COX-2 and mPGES-1 expression by activating the NF-κB signaling pathway and inducing the release of IL-1β (Viana et al. 2020), but this study failed to explore the regulatory role of BAP1 mutations on the NF-κB signaling pathway."
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"Expression of COX-2 and mPGES-1 are induced by BaP1 via activation of NF-kappaB pathway."
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"Having shown that the inducible COX-2 isoform participates in the signaling pathway triggered by BaP1 that leads to PGE production, we next investigated whether BaP1 is able to induce protein expression of COX-2 in FLSs."
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"Accordingly, our data show that BaP1 induced a marked increase in protein expression of both COX-2 and mPGES-1, the increase in COX-2 expression occurring before that of mPGES-1."
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"Furthermore, our findings that BaP1 induced gene expression of COX-2 and mPGES-1 demonstrate that BaP1 can trigger transcriptional mechanisms in FLSs that result in increased protein expression."
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"We found that the EP4 receptor positively regulates BaP1-triggered PGE release and expression of COX-2 and mPGES-1, which are critically involved in the biosynthesis of PGE induced by this metalloprotease."
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"Intriguingly, BAP1 was unfolded to increase the COX-2 and mPGES-1 expression by activating the NF-κB pathway (Viana et al. 2020)."
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"In view of previous reports that IL-1β induces PGE production via up-regulation of COX-2 and PGESm-1 expression in several cell types, including synovial fibroblasts , it is plausible to suggest that, under the present experimental conditions, IL-1β up-regulates BaP1-stimulated production of PGE by inducing expression of COX-2 and/or mPGES-1 in FLSs."
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