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This Service

A database built with INDRA combining content from numerous readers and databases. This page allows you to curate the loaded statements. For more information please see the manual.

This Project

INDRA is developed by indralabs, a part of the Harvard Medical School Laboratory of Systems Pharmacology.

This project, indra_db, is also developed by the indralab team. For more information on how we procure our sources, you can go here. This work was funded by ARO grant W911NF‐15‐1‐0544 under the DARPA Communicating with Computers program.

IndraLab

Statements

SOS1 binds EGFR and GRB2. 3 / 3

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sparser

"Upon EGF stimulation, SOS1 binds to phosphorylated EGFR through the adaptor protein GRB2, which then triggers RAS activation at the plasma membrane ."

25979753

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"Although the low-copy-number vector pBT(L) was the best in the case of EGFR-Grb2-Sos1 Y3H interaction, it may also cause reduced bait expression and lowered sensitivity for the detection of weaker protein interactions."

19050013

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bel

"In response to stimulation with epidermal growth factor (EGF), the guanine nucleotide exchange factor human SOS1 (hSOS1) promotes the activation of Ras by forming a complex with Grb2 and the human EGF receptor (hEGFR)"

8621459

Our Sources:

INDRA allows us to combine the results from a multitude of sources. In particular, the INDRA Database draws on the following...