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USP8 deubiquitinates PRKN. 12 / 13
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"The latter was in agreement with a previous study showing that USP8-dependent deubiquitination of Parkin is required for Parkin recruitment and activation following CCCP-induced mitochondrial stress [17]."
37190052
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"In addition, a recent study has shown that H S promoted mitophagy by increasing S-sulfhydration of ubiquitin-specific peptidase 8 (USP8), which in turn enhanced Parkin deubiquitination and recruitment to damaged mitochondria (Figure 4) [186]."
38929122
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"Durcan et al. demonstrated that USP8 plays a direct role in deubiquitinating parkin and preventing its auto-ubiquitination [39]."
37874827
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"At present, the negative regulatory mechanisms against Parkin-mediated ubiquitination have been reported, with the discovery of several deubiquitinases including USP8, USP15 and USP30 that are able to cause the deubiquitination of Parkin and/or OMM proteins."
29934616
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"In contrast to ataxin-3, USP8 deubiquitinated PARKIN directly, mediating the removal of Ub conjugates from PARKIN by specifically acting on the K6 linkages in these chains (Durcan et al. 2014)."
25995186
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"This process is negatively regulated by USP15 [XREF_BIBR] and USP30 [XREF_BIBR], which deubiquitinate mitochondrial Parkin-targets, while it is supported by USP8, which deubiquitinates Parkin itself [XREF_BIBR]."
25545884
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"USP8 KD delayed but not fully abolished Parkin translocation and mitophagy without affecting mitochondrial membrane potential, steady-state levels of PINK1, PINK1 accumulation on mitochondria, mitochondrial protein levels and ubiquitination, or mitochondrial morphology, fusion, fission, and fragmentation [50]."
36831318
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"Finally, deubiquitination of Parkin by USP8 is required for Parkin recruitment to CCCP intoxicated mitochondria and to promote stress induced mitophagy in vitro."
30988163
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"USP8 deubiquitylation of auto-ubiquitylated Parkin is required for its localization to depolarized mitochondria, and thereby for efficient activation of mitophagy [XREF_BIBR]."
26611876
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"Whilst the phosphatase that dephosphorylates p-Ub remains unknown, two DUBs have been identified that deubiquitylate Parkin directed substrates, USP30 and USP15, and USP8 has also been reported to reverse Parkin autoubiquitylation."
28408429
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"Studies have shown that in diabetic heart tissue, USP8 promotes mitophagy by deubiquitinating Parkin and facilitating the recruitment of Parkin to mitochondria, thereby protecting from myocardial injury (104)."
38322269
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"Indeed, when using mutant ubiquitin lacking K6, USP8 is unable to deubiquitinate PARK2."
25700639