IndraLab
Statements
reach
"Additionally, to evade host innate immunity, Hr-HPV can inhibit PRR signaling through the induction of ubiquitin C-terminal hydrolase L1 (UCHL1) expression; UCHL1 blocks the activation of NF-kappaB and IRF3, both of which are transcription factors that induce the production of proinflammatory cytokines and chemokines XREF_BIBR."
reach
"Overexpression of the UCHL1 gene significantly attenuated tumor necrosis factor (TNF)-alpha-induced NF-kappaB activity in vascular cells and increased inhibitor of kappa B-alpha (IkappaB-alpha), possibly through the attenuation of IkappaB-alpha ubiquitination, leading to decreased neointima in the balloon injured artery."
reach
"These data together suggest that UCHL1 also negatively regulates the NF-kappaB and STAT1 pathway to inhibit the immunosuppressive capacity and IDO expression of human MSCs, indicating an essential role of UCHL1 to regulate the immunosuppressive capacity of both human and murine MSCs."