IndraLab

Statements

USP10 leads to the deubiquitination of mutated FLT3. 2 / 2
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"In addition to mutant FLT3–ITD, another spleen tyrosine kinase (SYK), a critical regulator of FLT3, was deubiquitinated and stabilized by USP10; depleting or inhibiting USP10 reduced the expression of SYK, which promoted the proliferation of Ba/F3 and MOLM14 cells [68,84]."
35627217
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"Given our recent finding that USP10 deubiquitinates mutant FLT3, 18 coupled with reported studies showing that FLT3 and SYK are interacting partners with each other and are targets of the same E3 ligase c-CBL, XREF_BIBR, XREF_BIBR, XREF_BIBR - XREF_BIBR we hypothesised that USP10 may play a role in stabilisation of SYK."
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