IndraLab

Statements

Oligonucleotide inhibits TLR7. 2 / 2
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"By contrast, substitution of 2′-O-methyl-C, 2′-O-methyl-5-methyl-C or 5-methyl-dC for C or 2′-O-methyl-G for G leads to loss of immune-stimulatory activity; further, such oligos inhibit TLR7- and TLR9-mediated immune responses ( xref )."
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"Although the inhibitory effect of select LNA/DNA AMOs was surprising, it is consistent with a previous report that phosphorothioate DNA oligonucleotides can inhibit TLR7 sensing in a sequence-dependent manner ( xref )."
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