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USP14 deubiquitinates CCNB1. 4 / 4
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"Furthermore, it was found that USP14 promoted G2/M cell cycle transition of breast cancer cells by deubiquitinating and upregulating Cyclin B1 [10]."
37302347
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"Liu et al. found that USP14 modulated the cell cycle progression of breast cancer cells by deubiquitinating cyclin B1, a critical regulator of the mitotic phase (M phase) (Yu et al., 2002; Porter and Donoghue, 2003; Ding et al., 2014; Liu et al., 2019)."
35069211
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"Inhibition or knockdown of USP14 significantly augmented the ubiquitination of cyclin B1 and arrested the cell cycle at the G2/M phase, thereby inhibiting the proliferation and migration of breast cancer cells, and offering the theoretical basis for the development of USP14-targeted anticancer drugs (Table 2) (Liu et al., 2019)."
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"<span class="match term1">CyclinB1</span> deubiquitination by <span class="match term0">USP14</span> regulates cell cycle progression in breast cancer"
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