IndraLab
Statements
COPS5 activates Proteasome. 3 / 3
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3
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"Independently, IFIT proteins may modulate expression of negative regulators of the cell cycle, resulting in the accumulation of cells at the G 1 / S phase transition 60; ectopic expression of IFIT3 in U937 human myeloid cells resulted in sequestration of c-Jun activation domain binding protein-1 (JAB1), which limited ubiquitin and proteasome dependent degradation of cyclin dependent kinase inhibitor 1B (also known as p27 or KIP1)."
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"Indeed, ectopic expression of IFIT3 in U937 human myeloid cells resulted in the sequestration of JUN activation domain-binding protein 1 (JAB1; also known as COPS5), which limited ubiquitin- and proteasome-dependent degradation of cyclin-dependent kinase inhibitor 1B (also known as p27 and KIP1)."
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"Down-regulation of human CSN4 or CSN5 induced proteasome mediated degradation of the ubiquitin conjugating enzyme UBC3 and Cdc34."