IndraLab

Statements

COPS5 activates Proteasome. 3 / 3
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"Down-regulation of human CSN4 or CSN5 induced proteasome mediated degradation of the ubiquitin conjugating enzyme UBC3 and Cdc34."
20378537
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"Indeed, ectopic expression of IFIT3 in U937 human myeloid cells resulted in the sequestration of JUN activation domain-binding protein 1 (JAB1; also known as COPS5), which limited ubiquitin- and proteasome-dependent degradation of cyclin-dependent kinase inhibitor 1B (also known as p27 and KIP1)."
23237964
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"Moreover, downregulation of JAB1 induced proteasome-mediated degradation of the ubiquitin-conjugating enzyme UBC3, which was targeted for ubiquitination and degradation by the cullin-RING ubiquitin ligase SCF (Fernandez-Sanchez et al. 2010)."
37365502