IndraLab

Statements


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reach
"USP1 binds FANCI directly via its SUMO like domain SLD2, which associates with the SUMO like domain interacting motif (SIM) on FANCI."

reach
"UAF1 SLD2 binds directly to a SIM in FANCI, bridging the interaction between USP1 and UAF1 and FANCD2 and FANCI."

sparser
"Our data demonstrates that increasing FANCI/D2 monoubiquitination by impairing USP1 is associated with the suppressed phosphorylation of ubiquitination-linked FANCI sites."