IndraLab

Statements

SETD7 methylates TP53 on K372. 31 / 31
2 2 | 19 8
reach
"Chuikov et al. showed that SET9 can specifically methylate p53 at K372 ."
30926778
reach
"Furthermore, we have shown that methyltransferase Set7/9 that methylates p53 on K372 also interacts with Mdm2 thereby sequestering it away into a non functional complex thereby increasing acetylation and stabilization of the former [XREF_BIBR, XREF_BIBR]."
29290977
reach
"P53 pre-methylated at lysine 372 (p53K372 mono-methylation) by SET7 protects p53 from E6 induced degradation."
21963854
reach
"SETD7 methylates p53 at K372, enhancing p53 stability and its transcriptional activity."
30535125
reach
"For example, Set7/9 methylates p53 on K372, which augments acetylation of K373 and K382 [XREF_BIBR]."
24298606
reach
"However, some reports have pointed out that SET9 can dimethylate Lys372 of p53 (p53-K372) and Lys4 of histone H3 (H3-K4)."
21625555
reach
"In 2004, they showed that Set7 and Set9 monomethylates p53 at lysine 372 (p53K372me1) [XREF_BIBR]."
24561874
reach
"SMYD2 mono-methylates p53 on lysine K370 (p53K370me1), XREF_BIBR, XREF_BIBR while SET7 monomethylates p53 on lysine K372 (p53K372me1) XREF_BIBR in the regulatory domain."
23625014
biopax:pid
No evidence text available
15525938
sparser
"Recently, we discovered that lysine methylation of p53 at K372 by Set7/9 (also known as SET7 and Set9) is important for transcriptional activation and stabilization of p53."
17646389
reach
"For example, Set7 methylates p53 at K372, and this methylation has been reported to stabilize p53 (Chuikov et al., 2004)."
25042802
reach
"It has recently been shown that p53 can be methylated at K372 by Set9 methyltransferase, [XREF_BIBR] and that the PHD finger of ING1/2 is required for p53 activity."
19184981
reach
"In particular, Set7/9 (KMT7)-mediated monomethylation of human p53 at lysine 372 (p53K372me1) was suggested to be essential for p53 activation in human cell lines."
21855805
hprd
No evidence text available
16415881
reach
"In this paper, the authors demonstrated that upon DNA damage, SET9 mono-methylation of p53 at lysine 372 (p53K372me1; see XREF_FIG) in the nucleus results in stabilization of chromatin bound p53."
21826189
reach
"Indeed, the first example of a histone KMT with dual activity was shown by Reinberg and colleagues, who showed that SETD7 monomethylates p53 at K372 to positively regulate p53 protein stability."
27580749
hprd
No evidence text available
17108971
sparser
"Furthermore, we have shown that methyltransferase Set7/9 that methylates p53 on K372 also interacts with Mdm2 thereby sequestering it away into a non-functional complex thereby increasing acetylation and stabilization of the former [ xref , xref ]."
29290977
reach
"Similarly, lysine methylation can also change nuclear localization and regulate transcriptional activity.For example, previous research has demonstrated that SET7 specifically methylated p53 at lysine 372, and methylated p53-K372 localized to the nucleus ."
30926778
reach
"In 2004, Chuikov et al. found that K372 of p53 is mono-methylated by Set7/9 lysine methyltransferase [49]."
17306845
reach
"P53 methylation was first documented by the Reinberg group, who showed that SET9 (alias SET7) monomethylates p53 at K372 [XREF_BIBR]."
26305020
reach
"Methylation of p53 by the KMT7 (SET7/9) methyltransferase enzyme on Lys372 in the C-terminal region of the protein following DNA damage results in p53 stabilization and trans-activation of p53 target genes like p21 [XREF_BIBR]."
18923809
sparser
"Methylation of p53 at lysine 372 by Set9 methyltransferase leads to increased p53 stability and nuclear localization, resulting in increased expression of p53 target genes [ xref ]."
19243304
reach
"Among these enzymes is Set9, a histone methyltransferase, which efficiently methylates p53 and E2F1 at Lys 372 and Lys 185, respectively, with opposite consequences on their respective activities XREF_BIBR, XREF_BIBR."
23251702
sparser
"For example, previous research has demonstrated that SET7 specifically methylated p53 at lysine 372, and methylated p53-K372 localized to the nucleus xref ."
30926778
sparser
"For example, Set7/9 methylates p53 on K372, which augments acetylation of K373 and K382 [ xref ]."
24298606
sparser
"Specifically, the recognition of p53K370me2 by 53BP1 has the consequence of activating p53-dependent transcription. xref The DNA damaging agent adriamycine activates a p53-dependent response and induces the methylation of p53K372 by SET7. xref Chromatin signaling events leading to the methylation of p53 at K372 by SET7 could potentially prevent the modification of K370 by SMYD2 and diminish the association between p53 and 53BP1."
23625014
reach
"SETD7 methylation of p53 at K372 enhances its function by stabilizing p53 and inhibiting its nuclear export."
30013796
biopax:pid
No evidence text available
17646389
sparser
"SETD7 methylates p53 at K372, enhancing p53 stability and its transcriptional activity ( xref )."
30535125
sparser
"For example, Set7 methylates p53 at K372, and this methylation has been reported to stabilize p53 ( Chuikov et al., 2004 )."
25042802