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A database built with INDRA combining content from numerous readers and databases. This page allows you to curate the loaded statements. For more information please see the manual.

This Project

INDRA is developed by indralabs, a part of the Harvard Medical School Laboratory of Systems Pharmacology.

This project, indra_db, is also developed by the indralab team. For more information on how we procure our sources, you can go here. This work was funded by ARO grant W911NF‐15‐1‐0544 under the DARPA Communicating with Computers program.

IndraLab

Statements

SLC4A1 inhibits USP47. 2 / 2

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"Cells were treated with the following DIs: P22077, which specifically inhibits the DUBs USP7 and USP47 [59], the DI P5091, which only inhibits USP7 [60], and the DI PR-619, that, in addition to USP7 and USP47, inhibits the DUBs Josephin domain containing 2 (JOSD2), deneddylase 1 (DEN1), UCH-L3, UCH-L5, USP2, 4, 5, 8, 15, 20, and 28 [59]."

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"In this study , we could show that DIs , especially those inhibiting USP7 and USP47 , enhance the entry of Gag into the UPS and thus into the MHC-I pathway , indicating that specific DUBs play an important role in the regulation of Gag ubiquitination ."

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INDRA allows us to combine the results from a multitude of sources. In particular, the INDRA Database draws on the following...