IndraLab

"Somatic heterozygous mutations in the genes KCNJ5 coding for the potassium channel GIRK4, ATP1A1 coding for the α1 subunit of the Na + /K + -ATPase, ATP2B3 coding for the plasma membrane Ca 2+ -ATPase, type 3 PMCA3, and CACNA1D encoding the Cav1.3 voltage dependent calcium channel were identified in approximately 50% of APA. xref - xref These mutations are responsible for chronic zona glomerulosa cell membrane depolarization ( KCNJ5 and ATP1A1 mutations) leading to opening of voltage-dependent calcium channels, for impaired intracellular calcium recycling ( ATP2B3 mutations), or voltage-dependent calcium channel activation and opening at lower voltages ( CACNA1D mutations). xref – xref All these genetic abnormalities converge towards an increase in intracellular calcium concentration and activation of calcium signaling, which plays a central role in the regulation of aldosterone production, in particular by increasing the expression of CYP11B2 encoding aldosterone synthase."

"While these putative functional NMDA receptors are generally assumed to be at axonal locations, the existence of presynaptic, axonal NMDA receptors has been challenged by the discovery that somatodendritic NMDA receptor activation can affect axonal Ca 2+ levels through voltage-dependent calcium channel activation, at least in cerebellar stellate cells (Christie and Jahr, xref )."

"The authors show that BDNF release from cultured cortical cells is dependent on both AMPAR and voltage-dependent calcium channel activation and that BDNF dose-dependently increases extracellular signal-regulated kinase 1/2 phosphorylation via a tropomyosin receptor kinase B–dependent mechanism."

"Conversely, when K channels close, intracellular free Ca 2+ increases as a result of voltage-dependent calcium channel activation and vessels constrict."

"Another GWAS (n=2323) observed trending associations (ie, p<0.05, but not genome-wide significance) between CACNA1C variants and both increased sleep latency (p<0.0001) and poorer sleep quality (p<0.0001). xref Another study found no significant association between variants and sleep latency (n=2034); xref however, a candidate gene study observed associations between CACNA1C variants and poor sleep quality (p<0.017). xref Furthermore, the rare, homozygous recessive genotype (three of 932 individuals) for this CACNA1C variant was associated with reduced sleep latency (p<0.005) and higher reports of depressive symptoms (p<0.001). xref CACNA1C encodes an L-type voltage-dependent calcium channel activated by the wake-promoting neuropeptide orexin, and has been implicated in depression, bipolar disorder, schizophrenia, and one small (n=602) candidate gene study of narcolepsy ( xref , xref )."

"Under these conditions, X-Rhod-5F and Fluo4-FF could detect calcium changes (signal twice that of noise) in the dendrite due to voltage dependent calcium channel activation after single action potentials while with the same criterion GCaMP required 5 action potentials, camgaroo-2, 33, and inverse pericam over 20."

"SCA6 is caused by a polyQ mutation in the calcium channel gene CACNA1A (Zhuchenko et al., 1997)."

"It triggers potassium ions (K + ) efflux, which prevents voltage-dependent calcium channel activation, leading to a decrease of the intracellular calcium concentration and relaxation of vascular SMC [ xref ]."

"KCNJ5 and ATP1A1 mutations are responsible for chronic zona glomerulosa cell membrane depolarization leading to opening of voltage-dependent calcium channels, while ATP2B3 mutations affect intracellular calcium recycling and CACNA1D mutations lead to voltage-dependent calcium channel activation and opening at lower voltages ( xref , xref , xref , xref )."

"These authors found that neuronal activity such as NMDA receptor-dependent calcium influx or voltage-dependent calcium channel activation resulted in either receptor disassembly or clustering, respect[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"

"Toxic-dose bupivacaine-induced relaxation appears to be partially associated with the inhibition of voltage-dependent calcium channel activated by phenylephrine in endothelium-denuded rat aortas."

"Specifically, post-synaptic eCB synthesis, initiated via voltage-dependent calcium channel activation or G-protein coupled receptor (GPCR)-dependent mechanisms, results in release and diffusion of eCBs into the synaptic cleft ( xref )."

"SCaTs were observed in the basket terminals at frequencies that were significantly increased after bath application of 10 microm ryanodine and did not depend on P/Q- or N-type voltage-dependent calcium channel activation."

"The above results show that spontaneous Ca ++ oscillations in OLs are generated in response to voltage-dependent calcium channel activation."

"Induced rather than basal VEGF release in RPE is thought to be controlled by different mechanisms, including voltage-dependent calcium channel (VDCC) activation and mitogen-activated protein kinases."

"When K + channels close, become dysfunctional, or their expression is down regulated, the cell depolarizes and intracellular Ca 2+ increases as a result of voltage-dependent calcium channel activation."

"In addition to a potential direct contribution to calcium influx, Trpc channels are thought to promote calcium entry by providing a depolarizing stimulus (sodium and calcium currents) for voltage-dependent calcium channel activation and subsequent smooth muscle cell contraction [ xref , xref ]."

"Studies in primary neuronal cultures provide direct evidence that ketamine increases BDNF release in an activity dependent manner that also requires L-type voltage dependent calcium channel (VDCC) activation ( xref )."

"It has been hypothesized that L-type voltage-dependent calcium channel activation or locally generated, spatially restricted dendritic spikes in proximal dendrites could contribute to postsynaptic depolarization and calcium entry, which shifts the balance to LTP rather than LTD in this region (Golding et al., xref ; Parvez et al., xref )."

"Third, Ang IV increases Ca 2+ levels via L-type voltage-dependent calcium channel activation, leading to post-synaptic modulations to enhance synaptic transmission and long-term potentiation (LTP) [ xref ]."

"Broad spikes are dependent on voltage-dependent calcium channel activation."