IndraLab

Statements

COPS5 activates cisplatin. 13 / 13
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"By contrast, exogenous Jab1 expression enhanced the resistance of NPC cells to cisplatin, IR and UV radiation."
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"In conclusion, we demonstrated that Jab1 contributes to the sensitivity and resistance of NPC cells to cisplatin and irradiation."
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"On the basis of our previous findings, we hypothesized that Jab1 contributes to cisplatin, IR and UV resistance."
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"Recently, we found that the aberrant activation of Jab1 overexpression is correlated with a lower survival rate in NPC patients 14 and that Jab1 positively regulates the DNA repair gene Rad51 and contributes to NPC cells ' response to radiotherapy and cisplatin 15."
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"Jab1 depletion also enhanced the antitumor effects of cisplatin in NPC cells."
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"Depletion of Jab1 by siRNA, which leads to inhibition of proliferation, enhanced cisplatin activity in NPC."
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"By contrast, exogenous Jab1 expression enhanced the resistance of breast cancer cells to adriamycin and cisplatin."
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"Moreover, Jab1 depletion enhanced the antitumor effects of cisplatin in NPC cells."
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"By contrast, exogenous Jab1 expression enhanced the resistance of NPC cells to cisplatin, IR and UV Moreover, we provide a mechanism by which Jab1 positively regulated Rad51 through p53 dependent pathway, and increased ectopic expression of Rad51 conferred cellular resistance to cisplatin, IR and UV in Jab1 deficient cells."
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"The current finding that Jab1 positively regulates Rad51 and contributes to the response of NPC cells to cisplatin, IR and UV suggests that assessing the Jab1 level in patients may help predict response to cisplatin and radiation treatments, allowing the design of individualized treatment strategies for patients with NPC."
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"Similarly, the levels of phospho-Chk2, a key molecule in transducing DNA damage signals, were increased after cisplatin and UV exposure regardless of whether the cells were treated with Jab1 siRNA (although the phospho-Chk2 levels were higher in Jab1 deficient cells)."
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"These observations suggested that Jab1 and CSN5 is a major contributor to the resistance of NPC to UV radiation, IR, and cisplatin."
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"Jab1 depletion enhances the antitumor effects of cisplatin in NPC."
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