IndraLab

"NEMO ubiquitylation is decreased through the deubiquitinase USP10, which interacts with NEMO via MCPIP1 upon genotoxic stress."

"Moreover, usp4-depleted zebrafish (Danio rerio) larvae have been shown to produce more proinflammatory cytokines and were more susceptible to endotoxic challenge following LPS treatment. [102] Ubiquitin carboxyl-terminal hydrolase L1 (UCHL1) cleaves K63-linked polyubiquitin chains on TRAF3, which ultimately leads to reduced production of type I IFN, proinflammatory cytokines, and chemokines in response to highrisk human papillomavirus (hrHPV) infection. [103] TRAF family member-associated NF-B activator (TANK) interacts with both monocyte chemotactic protein-1-induced protein-1 (MCPIP1) and USP10, leading to the cleavage of ubiquitin chains on TRAF6 and termination of NF-B activation in response to TLR activation. [104] Of note, USP10 also interacts with NEMO via MCPIP1 and leads to the removal of NEMO-attached M1-linked polyubiquitin chains, thus inhibiting the genotoxic NF-B signaling cascade. [40] In addition to interacting with USP10, MCPIP1 itself regulates cellular inflammation pathways with distinct mechanisms."

"Moreover, usp4 ‐depleted zebrafish ( Danio rerio ) larvae have been shown to produce more proinflammatory cytokines and were more susceptible to endotoxic challenge following LPS treatment. [ xref ] Ubiquitin carboxyl‐terminal hydrolase L1 (UCHL1) cleaves K63‐linked polyubiquitin chains on TRAF3, which ultimately leads to reduced production of type I IFN, proinflammatory cytokines, and chemokines in response to high‐risk human papillomavirus (hrHPV) infection. [ xref ] TRAF family member‐associated NF‐ κ B activator (TANK) interacts with both monocyte chemotactic protein‐1‐induced protein‐1 (MCPIP1) and USP10, leading to the cleavage of ubiquitin chains on TRAF6 and termination of NF‐ κ B activation in response to TLR activation. [ xref ] Of note, USP10 also interacts with NEMO via MCPIP1 and leads to the removal of NEMO‐attached M1‐linked polyubiquitin chains, thus inhibiting the genotoxic NF‐ κ B signaling cascade. [ xref ] In addition to interacting with USP10, MCPIP1 itself regulates cellular inflammation pathways with distinct mechanisms."

"Moreover, usp4‐depleted zebrafish (Danio rerio) larvae have been shown to produce more proinflammatory cytokines and were more susceptible to endotoxic challenge following LPS treatment.[ 102 ] Ubiquitin carboxyl‐terminal hydrolase L1 (UCHL1) cleaves K63‐linked polyubiquitin chains on TRAF3, which ultimately leads to reduced production of type I IFN, proinflammatory cytokines, and chemokines in response to high‐risk human papillomavirus (hrHPV) infection.[ 103 ] TRAF family member‐associated NF‐κB activator (TANK) interacts with both monocyte chemotactic protein‐1‐induced protein‐1 (MCPIP1) and USP10, leading to the cleavage of ubiquitin chains on TRAF6 and termination of NF‐κB activation in response to TLR activation.[ 104 ] Of note, USP10 also interacts with NEMO via MCPIP1 and leads to the removal of NEMO‐attached M1‐linked polyubiquitin chains, thus inhibiting the genotoxic NF‐κB signaling cascade.[ 40 ] In addition to interacting with USP10, MCPIP1 itself regulates cellular inflammation pathways with distinct mechanisms."