IndraLab

Statements

UCHL1 inhibits APP. 16 / 18
| 1 15
reach
"Our results indicated that UCHL1 promoted the degradation of APP via the lysosomal pathway."
25466238
reach
"In APP and PS1 mice, injection of UCH-L1 improves the retention of contextual learning through the PKA-CREB pathway [XREF_BIBR] and reduces Abeta production, increased free ubiquitin and accelerates proteosomal degradation of APP [XREF_BIBR]."
28153028
reach
"In APP and PS1 mice, injection of UCH-L1 improves the retention of contextual learning through the PKA-CREB pathway [XREF_BIBR] and reduces Abeta production, increased free ubiquitin and accelerates proteosomal degradation of APP [XREF_BIBR]."
28153028
reach
"Disruption of UCHL1 gene expression significantly increased APP CTFs in the hippocampi of APP23 and gad mice compared to APP23 mice (XREF_FIG)."
25466238
eidos
"In SH-SY5Y cells , overexpression of ciRS-7 reduced Abeta deposition by upregulating UCHL1 to degrade APP and BAEC1 , but these effects were reversed with inhibition of NF-kB signaling ."
35048805
reach
"Over-expression of UCHL1 decreased APP C-terminal fragment C99 and Abeta levels in HUCH cells."
22212137
reach
"This may be mechanistically attributed to the fact that loss of UCHL1 and UCHL3 accelerates the degradation of APP, thus accounting for the overproduction of Aβ (Zhang, Cai, Zhang, Zhang, & Song, 2014) (Table 2).2.5 Therapeutic implications."
29992725
reach
"Zhang et al. reported that the overexpression of UCHL1 decreased Abeta in the uchl1-null AD mice (Zhang et al., 2012)."
24950120
reach
"UCHL1 also accelerates beta-secretase degradation, impairs APP processing and decreases Abeta 109."
27028664
reach
"The mechanism by which Uch-L1 reduces Abeta accumulation and toxicity is unclear."
26858599
reach
"The Uchl1 overexpression, induced by intracranial injection of Uchl1 expressing virus, decreases the Abeta production and protects AD model mice against memory impairment."
29441009
reach
"Our data also suggest that ciRS-7 modulates APP and BACE1 levels in a nuclear factor-kappaB (NF-kappaB)-dependent manner : ciRS-7 expression inhibits translation of NF-kappaB and induces its cytoplasmic localization, thus derepressing expression of UCHL1, which promotes APP and BACE1 degradation."
28296235
reach
"The expression of ciRS-7, UCHL1, and p65 was significantly upregulated after breviscapine or BMSCs treatment, and there was increased APP and BAEC1 degradation."
35048805
reach
"UCH-L1 null mice have higher levels of brain Abeta, while overexpression of UCH-L1 slows the deposition of Abeta and attenuates cognitive decline in a mouse model of AD (Zhang et al., 2012)."
29933008
reach
"Facilitation of APP degradation by UCHL1 could be through the lysosomal or proteasomal pathway."
25466238
reach
"Other work proposes that UCHL1 has specific substrates and may increase UPP dependent degradation of the beta-site amyloid precursor protein (APP) cleaving enzyme 1 (BACE1)."
25191222