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AKT phosphorylates MAP3K5. 32 / 34
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"It has been shown that SIRT1 activates Akt, which in turn can phosphorylate ASK1 at Ser 83 to maintain ASK1 in an inactive form XREF_BIBR."
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"An important role for Akt in forestalling apoptosis has been shown in the case of poliovirus, where the Akt phosphorylation of Ask1 limits the activity of its downstream effector Jnk1 and thereby decreases apoptotic signals."
22340720
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"Through the pancreatic cancer cell line PANC-1, Mochizuki group reveals that inhibition of AKT phosphorylation of ASK1 alone was sufficient in inducing apoptosis."
22581366
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"Ling et al previously demonstrated that CHI3L1 stimulation in human skin fibroblasts or articular chondrocytes resulted in protein kinase B (Akt)-mediated serine/threonine phosphorylation of the apoptosis signal-regulator kinase, ASK1, suggesting that CHI3L1 elicits anti-catabolic and anti-apoptotic response during tissue remodeling and destruction [XREF_BIBR]."
21546314
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"Another substrate of Akt is the apoptosis signal-regulating kinase 1 (ASK1); Akt phosphorylation of ASK1 prevents apoptosis induced by serum deprivation ( Kim et al., 2001b )."
12646285
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"Apoptosis signal-regulating kinase 1 (ASK1) also activates the p38 MAPK cascade, but Hsp90-Akt phosphorylates ASK1 and inhibits ASK1-mediated apoptosis xref ."
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"In summary, phosphorylation of Ask1 by Akt promotes survival, perhaps by keeping JNK at low levels and thus avoiding JNK-induced apoptosis, and by producing moderate levels of phospho-p38."
36353511
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"Indole 1 also inhibited AKT-mediated mTOR phosphorylation in a time dependent manner as well as the anti-apoptotic factor Bcl-2 and AKT-dependent phosphorylation of ASK1, while pro-apoptotic proteins like p53 and p21 were up-regulated."
23272910
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"At intermediary cascade level, Akt is able to phosphorylate and inhibit the activity of ASK1 and MLK3 that belong to the MAPKKK upstream activation of JNK, and the final effect is the decrease of ASK1- and MLK3 mediated cell death [XREF_BIBR, XREF_BIBR]."
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"Studies show that AKT and PKB negatively regulates the phosphorylation and activation of JNK by directly phosphorylating apoptosis signal regulating kinase 1 (ASK1) and JNK interacting protein 1 (JIP1) [XREF_BIBR, XREF_BIBR]."
27657053
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"Further, CDKN1A is also able to promote survival through the phosphorylation by AKT and subsequent direct binding to effector caspases and MAP3K5 XREF_BIBR, XREF_BIBR."
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"A recent report shows that PKB phosphorylates and inactivates apoptosis signal-regulating kinase-1 (Kim et al., 2001) , a mitogen-activated protein kinase kinase kinase that mediates stress- and cyto[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
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"Indole 1 also inhibited AKT mediated mTOR phosphorylation in a time dependent manner as well as the anti-apoptotic factor Bcl-2 and AKT dependent phosphorylation of ASK1, while pro apoptotic proteins like p53 and p21 were up-regulated."
23272910
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"A recent report shows that PKB phosphorylates and inactivates apoptosis signal regulating kinase-1 (Kim et al., 2001), a mitogen activated protein kinase kinase kinase that mediates stress- and cytoki[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
12191616
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"Akt directly phosphorylates and inactivates the pro-apoptotic proteins ASK1, BAD, caspase 9 [ xref - xref ]."
12057025
rlimsp
"Yuan and his collegues also proved that AKT can inhibit the cisplatin-induced p38 activation through phosphorylation of ASK1 [53]."
22194952
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"Although ASK1 can be phosphorylated by both PIM1 and AKT, there are differences between these two kinases."
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"Interestingly, Akt phosphorylates and negatively regulates the MAPKKK apoptosis signal-regulating kinase 1 (Ask1) ( xref )."
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"One mechanism is that Akt phosphorylates Ask (apoptosis signal regulating kinase 1) and inhibits pro apoptotic function in intestinal epithelial cells."
19454725
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"13,24 In this respect, it has been shown recently that Akt can phosphorylate and inhibit MEKK3 and ASK-1, consequently impacting negatively on MKK3/6 activation and thus p38 stimulation."
12454855
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"Another substrate of Akt is the apoptosis signal regulating kinase 1 (ASK1); Akt phosphorylation of ASK1 prevents apoptosis induced by serum deprivation (Kim et al., 2001b)."
12646285
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"Akt directly phosphorylates several pro apoptotic proteins, including procaspase 9, the Bcl-2 family member BAD, and apoptosis signal regulating kinase-1 (ASK1), resulting in their inactivation [XREF_BIBR - XREF_BIBR]."
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"Akt phosphorylates and negatively regulates apoptosis signal-regulating kinase 1."
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"For example, Akt phosphorylates the pro apoptotic Bcl-2 family member BAD, XREF_BIBR, XREF_BIBR caspase-9 27 and apoptosis signal regulating kinase 1 (Ask1) 28 and inhibits their pro apoptotic functions."
22450747
trips
"Akt phosphorylates and negatively regulates apoptosis signal-regulating kinase 1."
11154276
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"An important role for Akt in forestalling apoptosis has been shown in the case of poliovirus, where the Akt phosphorylation of Ask1 limits the activity of its downstream effector Jnk1 and thereby decreases apoptotic signals.Cardioviruses also appear to manipulate Akt activity to limit apoptosis in infected cells."
22340720
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"Studies show that AKT and PKB negatively regulates the phosphorylation and activation of JNK by directly phosphorylating apoptosis signal regulating kinase 1 (ASK1) and JNK interacting protein 1 (JIP1) [XREF_BIBR, XREF_BIBR]."
27657053
reach
"In summary, phosphorylation of Ask1 by Akt promotes survival, perhaps by keeping JNK at low levels and thus avoiding JNK-induced apoptosis, and by producing moderate levels of phospho-p38."
36353511
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"It is reported that ASK1 phosphorylation by the PI3K and Akt pathway could reduce apoptosis induced by transfected ASK1 in 293T and HeLa cells."
25116390
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"Akt directly phosphorylates and inactivates the pro apoptotic proteins ASK1, BAD, caspase 9 [XREF_BIBR - XREF_BIBR]."
12057025
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"13,24 In this respect, it has been shown recently that Akt can phosphorylate and inhibit MEKK3 and ASK-1, consequently impacting negatively on MKK3/6 activation and thus p38 stimulation."
12454855
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"Incidentally, Akt phosphorylates ASK-1 (on S83) as part of its pro-survival functions, thus keeping the latter's activation in check (Figures xref - xref ) [ xref – xref , xref , xref ]."
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