IndraLab

Statements

Modified CUL4B decreases the amount of TSC2. 4 / 4
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"On the other hand, XLMR mutant (R388X), (R572C) or (V745A) CUL4B overexpressed in 293 cells failed to significantly decrease the protein level of TSC2."
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"In contrast, XLMR mutant (R388X), (R572C) or (V745A) CUL4B stably expressed in HEK 293 cells did not downregulate the protein expression of TSC2 or cyclin E."
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"In contrast to wild-type CUL4B, overexpression of XLID mutant (R388X), (R572C) or (V745A) CUL4B failed to downregulate protein expression of TSC2 or cyclin E in cultured neocortical neurons."
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"shRNA mediated knockdown of CUL4B protein level greatly upregulated protein expression of cyclin E or TSC2 in cultured neocortical neurons.Knockdown of CUL4B induced upregulation of TSC2 in neocortica[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
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