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PAN2 activates RBBP8. 1 / 1

1 |

"Here, we identify that USP52 directly interacts with and deubiquitinates CtIP, thereby promoting DNA end resection and HR. Mechanistically, USP52 removes the ubiquitination of CtIP to facilitate the phosphorylation and activation of CtIP at Thr-847. In addition, USP52 is phosphorylated by ATM at Ser-1003 after DNA damage, which enhances the catalytic activity of USP52."

33097710

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IndraLab

Statements

PAN2 activates RBBP8. 1 / 1

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