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Mutated BAP1 activates DNA Damage. 1 / 1

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"However, the spontaneous development of mesotheliomas in Bap1 +/- mice not exposed to asbestos, and the development of multiple cancer types in carriers of BAP1 mutations (XREF_FIG), including tumor types that have not been associated with known carcinogens, suggests that BAP1 mutations also drive tumor growth independently of genotoxic stress, perhaps by favoring the accumulation of age related DNA damage."

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Mutated BAP1 activates DNA Damage. 1 / 1

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