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Mutated BAP1 activates DNA Damage. 3 / 3
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"Our findings suggested that BAP1 mutation, as a loss of function, upregulated the TCA cycle and initiated DNA damage through ROS accumulation, resulting in PARP1 hyperactivation–induced cell apoptosis (Figure 4P)."
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"BAP1 mutations enable mesothelial cells to evade apoptosis and accumulate further DNA damage, leading to carcinogenesis."
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"However, the spontaneous development of mesotheliomas in Bap1 +/- mice not exposed to asbestos, and the development of multiple cancer types in carriers of BAP1 mutations (XREF_FIG), including tumor types that have not been associated with known carcinogens, suggests that BAP1 mutations also drive tumor growth independently of genotoxic stress, perhaps by favoring the accumulation of age related DNA damage."
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