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USP22 activates epithelial to mesenchymal transition. 35 / 38
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"These results indicate that USP22 increases CRC cell migration and invasion abilities by promoting EMT."
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"Subsequent experiments showed that USP22 knockdown resulting from up-regulation of miR-30e-5p could inhibit proliferation, invasion, migration, and EMT in 5-8F cells."
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"As expected, silencing of USP22 has been proved to reverse the EMT phenotype of DDP-resistant TNBC cells in the present study."
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"Moreover, USP22 promotes epithelial–mesenchymal transition (EMT) in a variety of cancers by upregulating TGF-β1 expression [ 70 ], activating protein-activating enhancer binding protein 4 (AP4) [ 71 ][MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
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"In the meantime, USP22 overexpression aggravated the EMT phenotype of TNBC cells, which revealed that USP22 contributes to the EMT process in TNBC.The causative role of glycolysis in stemness and EMT [MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
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"These findings suggested that USP22 promotes melanoma metastasis both in vitro and in vivo.2.3 Elevated USP22 induces EMT activation in melanoma."
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"These results demonstrated that USP22 might promotes melanoma metastasis by inducing EMT activation.2.4 USP22 potentiates melanoma metastasis and EMT through activating PI3K/Akt/mTOR pathway."
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"USP22 silencing inhibits the proliferation, invasion, and EMT of OS cells in vitro ."
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"In the context of EMT induction, miR-30e is an important EMT inhibitor that works by targeting ITGB1, TUSC3, USP22, and SOX9 mRNAs, which reportedly induce EMT by activating transcription factors including SNAIL, SLUG, TWIST, and ZEB1/2 [XREF_BIBR, XREF_BIBR, XREF_BIBR, XREF_BIBR]."
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"The present study has revealled an additional novel mechanism by which USP22 induces EMT."
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"Aberrant USP22 expression can promote tumor progression and induce EMT in lung ADC [16, 19]."
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"Our in-depth examination demonstrated that AP4 acts as a downstream molecule of USP22 and is required for the promotion of EMT by USP22 and the increased migration and invasion of CRC cells."
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"These results suggested that USP22 potentiates melanoma metastasis and EMT through activating the PI3K/Akt/mTOR pathway.2.5 USP22 activates PI3K/Akt/mTOR pathway via SIRT1/PTEN axis."
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"In addition to promoting EMT, USP22 overexpression upregulated the expression of TGF-β1 and ECM components including FN, Collagen I, and Collagen Ⅳ under HG conditions ( Fig. 3 F)."
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"USP22 increases CRC cell migration and invasion by inducing EMT."
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"To explore the role of AP4 in the promotion of EMT by USP22, we knocked down AP4 in USP22-down-regulated cells to detect the changes in the expression levels of key factors involved in EMT."
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"Moreover, USP22 overexpression can promote EMT and TGF-beta expression, whereas USP22 knockdown can reverse EMT and reduce the metastasis of lung adenocarcinomas."
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"USP22 has been shown to induce cell cycle progression via BMI-1 and p-Akt pathways in colorectal carcinoma [37] and promote the epithelial-mesenchymal transition (EMT) by regulating EMT marker express[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
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"These results suggest that EMT induction by USP22 requires functional AP4."
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"These results suggested that overexpression USP22 induced EMT in lung adenocarcinoma cells.Moreover it is well known that TGF-beta1 stimulates the EMT in lung cancer cells [43]."
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"A more recently published report indicates that USP22 may promote tumor progression and induce EMT in colorectal carcinoma patients [ 13 ] ."
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"These results suggested that overexpression USP22 may cause EMT in lung adenocarcinoma cells."
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"Taken together, these results indicate that USP22 increases cell migration and invasion by inducing EMT by binding to the promoter of AP4 to activate its transcription."
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"Therefore, USP22 silencing impairs ATC cell migration and invasion by ablating EMT."
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"However, the functional role of USP22 as a DUB may also be a critical contributor to the process of USP22 induced EMT via epigenetic regulation, emphasizing the need to explore the epigenetic functions of USP22 in CRC metastasis."
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"These results indicated that USP22 deficiency reversed renal EMT and TIF in diabetic kidneys by blocking the Snail1 signaling pathway (see Fig. 11 )."
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"USP22 induces the occurrence of EMT in pancreatic cancer cells by activating FAK signaling."
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"These findings indicate that USP22 promotes CRC invasion and metastasis by inducing EMT via AP4 activation."
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"Some studies also revealed that USP22 can increase the invasion behavior of cancer cells by inducing EMT ( Hu et al., 2015 )."
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"The in vivo experimental results were basically consistent with the in vitro ones, indicating that USP22 stabilized the Snail1 protein and thus promoted renal EMT and diabetic TIF.USP22 promoted the o[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
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"Previous studies have also shown that USP22 can promote tumor progression and induce EMT in various tumors [ 13 , 23 ] ."
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"USP22 downregulation inhibited OS cell proliferation , invasion , and epithelial-mesenchymal transition ( EMT ) in vitro ."
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"USP22 overexpression enhances colon cancer migration and invasiveness by inducing EMT via activating AP4 (activating enhancer binding protein-4) transcription by binding to its promoter[54]."
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"According to the results of previous studies, USP22 can induce EMT by regulating TGF-beta1 in lung cancer cells [XREF_BIBR], and elevated USP22 expression can promote EMT by up-regulating ZEB1 and Snail in pancreatic cancer cells though a process that involves focal adhesion kinase (FAK) signaling [XREF_BIBR]."
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"In addition, we present evidence that USP22 promotes Bel/Fu cell growth, migration, invasion, EMT and chemoresistance."
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