IndraLab

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UCHL1 activates reactive oxygen species. 5 / 5
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"Because silencing UCH-L1 inhibited the phosphorylation of VEGFR, a signal for angiogenesis, this finding provides another evidence that UCH-L1 promotes ROS generation in HUVECs, and plays a key role i[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
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"This suggests that UCH-L1 mediates ROS generation via NOXs in B16F10 cells overexpressing UCH-L1."
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"UCH-L1 induced active NOX4 by deubiquitination of NOX4, and then increased ROS which induce angiogenesis in HUVECs."
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"Because H 2 O 2 generating activity of NOX4 is negatively modulated by ubiquitination and UCH-L1 promotes ROS induced cell invasion and migration in HeLa cells by deubiquitinating the NOX4 [13], we in[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
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"These results indicate that UCH-L1 increases cellular ROS generation."
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