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USP25 inhibits IRF3. 10 / 11
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"The results showed that USP25-WT remarkably inhibited SEV induced activation of IFN-beta (XREF_FIG), IRF3 (XREF_FIG), NF-kappaB (XREF_FIG) and ISRE (XREF_FIG) in a dose dependent manner."
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"Interestingly, the genetic deletion of USP21 in macrophages enhances IRF3 activation, IFN production, and antiviral response."
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"We observed that overexpression of USP25 significantly inhibited SEV-induced activation of IRF3 and NF-κB (Figure 3A and B)."
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"The results showed that USP25-WT remarkably inhibited SEV-induced activation of IFN-β (Figure 6A), IRF3 (Figure 6B), NF-κB (Figure 6C) and ISRE (Figure 6D) in a dose-dependent manner."
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"We observed that overexpression of USP25 significantly inhibited SEV induced activation of IRF3 and NF-kappaB (XREF_FIG)."
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"Collectively, these findings suggest that USP25 inhibits RIG-I/MDA5-dependent type I IFN signaling.To better understand the effects of USP25 in SEV-induced type I IFN signaling, we assessed whether expression of USP25 disrupts SEV-induced activation of IRF3 and NF-κB, the two important transcriptional factors in type I IFN signaling."
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"USP21 inhibits RIG-I-CARD-mediated IRF3 activation and negatively regulates antiviral response."
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"To better understand the effects of USP25 in SEV induced type I IFN signaling, we assessed whether expression of USP25 disrupts SEV induced activation of IRF3 and NF-kappaB, the two important transcriptional factors in type I IFN signaling."
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"USP21 inhibits virus induced IRF3 activation via binding to and deubiquitinating RIG-I."
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"The results showed that USP25-WT remarkably inhibited SEV-induced activation of IFN-β ( Figure 6A ), IRF3 ( Figure 6B ), NF-κB ( Figure 6C ) and ISRE ( Figure 6D ) in a dose-dependent To further determine the levels at which USP25 negatively regulates type I IFN signaling, HEK-293T cells were transfected with DNA constructs encoding RIG-I, IPS-1, TRAF2, or TRAF6, together with IFN-β-Luc."
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