IndraLab

Statements

USP25 inhibits IRF3. 7 / 8
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"USP21 inhibits virus induced IRF3 activation via binding to and deubiquitinating RIG-I."
24493797
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"USP21 inhibits RIG-I-CARD-mediated IRF3 activation and negatively regulates antiviral response."
24493797
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"To better understand the effects of USP25 in SEV induced type I IFN signaling, we assessed whether expression of USP25 disrupts SEV induced activation of IRF3 and NF-kappaB, the two important transcriptional factors in type I IFN signaling."
24260525
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"We observed that overexpression of USP25 significantly inhibited SEV induced activation of IRF3 and NF-kappaB (XREF_FIG)."
24260525
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"Interestingly, the genetic deletion of USP21 in macrophages enhances IRF3 activation, IFN production, and antiviral response."
33138315
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"The results showed that USP25-WT remarkably inhibited SEV induced activation of IFN-beta (XREF_FIG), IRF3 (XREF_FIG), NF-kappaB (XREF_FIG) and ISRE (XREF_FIG) in a dose dependent manner."
24260525
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"PCV2 infection can reduce the K63-linked ubiquitination of STING through p38-MAPK pathway-mediated USP21 phosphorylation, which inhibits the phosphorylation and nuclear transportation of IRF3, thus inhibiting IFN-β induction [134]."
35891399