IndraLab

Statements

MAP3K5 bound to CIB1 inhibits MAP3K5. 3 / 3
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"Instead, CIB1 physically associates with ASK1, and thereby prevents ASK1 activation induced by MPP +."
28939911
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"Given that CIB1 directly binds ASK1 and thereby inhibits the MPP + -induced activation processes of ASK1, we reasoned that the blockade of ASK1 by CIB1 may be an important part of the mechanism by which CIB1 negatively regulates MPP + -mediated toxicity in dopaminergic neurons."
28939911
reach
"In resting cells, ASK1 is bound to either thioredoxin or CIB1, two known endogenous inhibitors of ASK1 [26,27]."
35798237