IndraLab

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SMAD7 inhibits SMAD3. 71 / 78
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"The use of Smad7 to block Smad3 effects differs from studies utilizing Smad3 knock-out mice as Smad7 would inhibit both Smad2 and 3 whereas Smad3 knock-out mice, on the other hand, are a selective and complete loss of Smad3."
21324395
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"Overexpression of Smad7 inhibits both Smad3 mediated renal fibrosis and NF-kappaB-driven renal inflammation."
26889404
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"Inhibition of Smad7 with a specific antisense oligonucleotide restores TGF-beta1 and Smad3 signaling, resulting in a marked suppression of inflammatory cytokine production."
19079231
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"While Smad7 represses Smad3 activation by TGF-beta, it does not reverse the inhibitory effect of TGF-beta on myogenesis, suggesting a different function in myogenic cells."
19995910
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"Whereas SMAD7 inhibits both TGF-beta and SMAD3 and BMP and SMAD1 signaling, SMAD6 is a relatively specific inhibitor of BMP signaling."
21696393
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"Smad7 was recently shown to antagonize TGF-beta-induced activation of signal transducing Smad2 and Smad3 proteins."
10781941
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"Similar results were evident following induction of the intracellular Smad2 and Smad3 antagonist Smad7 by hepatocyte growth factor in RLE-6TN cells [XREF_BIBR]."
20178607
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"Smad7, a negative feedback inhibitor, can block Smad2 and Smad3 access to TGF-beta receptor 1."
32253812
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"Furthermore, in RA, not only did the inhibition of Smad7 promote TGFbeta and Smad3 signalling and tissue fibrosis, but it also markedly enhanced NF-kappaB-driven inflammation [XREF_BIBR]."
33670735
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"Overexpression of Smad7 not only inhibits Smad3 mediated renal fibrosis such as collagen matrix expression including epithelial-mesenchymal transition, but also blocks NF-kappaB-driven renal inflammation including accumulation of macrophages and T cells in both glomeruli and tubulointerstitium and upregulation of renal IL-1, TNFalpha, ICAM-1, and iNOS."
21927575
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"Based on the identification of downstream events of TGF-beta signaling transduction over the past several years, TGF-beta1 has been shown to activate Smad2 and Smad3, which are negatively regulated by Smad7, an inhibitor of TGF-beta signaling, through the ubiquitin-proteasome degradation mechanism [XREF_BIBR]."
28171717
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"Additionally SMAD7 can inhibit SMAD2 and SMAD3 activity, thus blocking TGF-beta signaling and its effect on cancer promotion."
25344802
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"In inflamed mucosal tissue explants from patients with CD, inhibition of Smad7 also restores p-Smad3 and decreases proinflammatory cytokine production, an effect that is partially blocked by anti-TGF-beta1."
11518734
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"Because Smad7 can abrogate both Smad2- and Smad3 dependent responses, we sought to clarify the specific role of cellular Smad3 in PPAR-gamma suppression using mouse fibroblasts deficient in Smad3 XREF_BIBR."
21072170
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"Smad7 inhibits phosporylation of Smad2 and Smad3 by TGF-beta receptors and the activation of Smad1 by BMP receptors, whereas Smad6 inhibits phosporylation of Smad2, but not of Smad3."
10647776
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"We show that IL1B induced Smad 7 inhibits the nuclear localization of Smad 3, thereby bringing about transcriptional repression of Smad 3 dependent gastrin expression."
21445336
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"It is known that Smad7 inhibits TGF-beta signaling by associating with its receptor and thus preventing Smad2 and Smad3 access for phosphorylation XREF_BIBR, XREF_BIBR."
23139630
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"Smad6 and Smad7 inhibit Smad2 and Smad3 activation by competing with Smad2 and Smad3 for binding to the TGF-beta receptors [XREF_BIBR]."
15084245
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"Additionally, inhibition of Smad3 by overexpression of the inhibitory Smad7 protein or by treatment with the small molecule, halofuginone, dramatically reduces responses in animal models of kidney, lung, liver and radiation induced fibrosis."
15154911
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"Silencing SMAD7 can restore TGFbeta and SMAD3 signaling and result in the suppression of inflammatory cytokine production in patients with inflammatory bowel diseases [XREF_BIBR]."
26446848
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"We and others have reported that in mouse and human T cells, TGF-beta stimulation increases Smad7, which can inhibit TGF-beta-induced Smad3."
31553906
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"Smad7 is an inhibitory Smad and negatively regulates Smad2 and Smad3 activation by its negative feed-back mechanism."
21927575
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"In this study, we found that administration of AZ505 effectively inhibited phosphorylation of Smad3 and increased expression of Smad7 (an antagonist of Smad3) in vitro and in vivo, suggesting that SMYD2 is functionally linked to the TGF-β/Smad3 signaling pathway to induce its activation."
34143514
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"Nevertheless, SMAD7 over expression and SMAD2/3 knock-down did decrease IL1beta- induced CAGA 12 -luciferase activity and over expressed SMAD3 responded similarly to IL1beta stimulation in the CAGA 12[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
28943409
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"XREF_BIBR In turn, both NF-kappaB and Smad3 can increase the expression of Smad7, which competes for TGF-beta1 receptors and downregulates the TGF-beta1 and Smad3 pathway, providing negative feedback."
29970958
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"SAHA induced higher Smad7 levels and inhibited translocation of Smad3 to the nucleus, also when combined with IGF-1."
27687492
sparser
"In addition, Smad7 may inactivate Smad3 to protect kidneys from fibrosis by upregulating renal miR-29b but suppressing miR-192 and miR-21 ( xref )."
32258028
signor
"Smad6 and smad7, can prevent tgfb signaling by interacting either with the receptor or with smad2 and smad3."
9892110
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"Most importantly, Smad7 is an inhibitor of both Smad3 mediated renal fibrosis and NF-kappaB-driven renal inflammation."
26889404
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"Cumulatively, these findings support the concept that SMAD7 is a competitive inhibitor of SMAD3."
28543554
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"And Smad7 can block the function of smad3."
29032117
eidos
"PRMT1 activates SMAD3 by preventing SMAD7 activity downstream of the TGF-beta signaling pathway , and promotes EMT [ 49 ] ."
32859041
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"Moreover, this response in ERMS cells was independent of SMAD7 degradation or activation of SMAD2 and SMAD3."
32905449
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"Kato et al. also reported the upregulation of miR-192 in fibrotic kidney disease is associated with the activation of TGF-beta and Smad signaling, which regulates expression positively by Smad 3, and negatively by Smad7 dependent mechanism [56]."
32923747
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"And Smad7 negatively regulates the activation of Smad2 and Smad3 XREF_BIBR."
26080011
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"Increased expression of Smad7, an inhibitory Smad that binds TbetaRI, that can be induced by Jak and STAT signaling might also inhibit TGF-beta-induced Smad3 activation; however, TpIC decreased Smad7 mRNA expression (XREF_FIG)."
25526531
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"Under high glucose conditions, the overexpression of Smad7 blocked the activation of Smad2 and Smad3 in renal and vascular cells, resulting in the inhibition of collagen I synthesis XREF_BIBR."
32547319
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"This is evidenced by the finding that Smad7 is able to block the transient association of Smad2 and Smad3 with activin receptor complex upon ligand stimulation [33]."
12023024
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"Inhibiting Smad7 can restore the TGF-beta1 and Smad3 signaling and result in the suppression of inflammatory cytokine production in patients with inflammatory bowel diseases [XREF_BIBR, XREF_BIBR]."
22429929
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"SMAD7 also recruits E3 ubiquitin ligases to degrade TβRI, SMAD2 and SMAD3, creating a regulatory feedback loop in TGF-β signaling (Chen et al., 2018)."
35237156
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"Smad7 inhibits TGF-beta signaling by preventing activation of Smad2 or Smad3, whereas Smad6 inhibits TGF-beta signaling by preventing activation of Smad1, Smad5, or Smad8."
22164144
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"In addition, IFN-gamma induces expression of Smad7, an inhibitory Smad family member, and thus inhibits TGF-beta-induced activation of Smad3 [XREF_BIBR]."
24758615
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"By contrast, Smad7 inhibits Smad2 and Smad3 activation by causing the degradation of TbetaRI and Smads via the ubiquitin-proteasome degradation mechanism XREF_BIBR, XREF_BIBR, XREF_BIBR."
26889404
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"This is of particular interest when keeping in mind that Smad7 negatively regulates Smad3."
28146082
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"XREF_BIBR Although activated TGF-beta1 was abundant in the mucus, H. pylori infection results in increased expression of Smad7, which inhibits Smad3 functions."
24672653
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"Although this has not yet been directly investigated, it is likely that Smad7 may function similarly to prevent association and activation of Smad3 by the TGFbeta receptor.Our studies indicate one pot[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
9215638
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"Adenovirus mediated Smad7 overexpression inhibited TGF-beta1-induced nuclear accumulation of Smad3 and Smad4, and potentiated activated PSC proliferation."
16380081
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"Smad7 inhibits renal fibrosis by negatively regulating Smad2 and Smad3 activation via its negative feedback mechanism."
26889404
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"Smad7 is an inhibitor of Smad2 and Smad3, and it had confirmed the role of Smad7 and NF-kappaB crosstalk pathway in renal inflammation; In contrast, overexpression of Smad7 can inhibit the activation of NF-kappaB."
27803787
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"It has been recently announced to be discontinued the phase III trial; however, patients with Crohn 's disease have been treated with antisense oligonucleotides against SMAD7, which binds to the TGF-beta receptor, blocking TGF-beta1 signaling; inhibition of SMAD7 promotes TGF-beta-induced activation of SMAD2 and SMAD3 signal transducers, thereby activating TGF-beta1-mediated anti-inflammatory activities."
29321781
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"Phosphorylated SMAD3 binds to SMAD4 and is translocated to the nucleus, where, along with other transcription factors, it promotes transcription of genes encoding matrix proteins; SMAD3 activity is inhibited by SMAD7."
23020145
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"TGF-beta-induced Smad3 activation is inhibited by Smad7 and to a lesser extent by Smad6, and Smad6 and Smad7 both inhibit Smad1 and Smad5 activation in response to the TGF-beta-related bone morphogenetic proteins (BMPs)."
29907569
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"In MRC-5 cells, HBE secreted exosomal miR-21 decreased levels of Smad7 and activated the TGF-beta1 and Smad3 pathway."
33961985
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"It is known that Smad7, a negative regulator of TGF-receptor I (TBRI) kinase, disrupts the activation of Smad2 and Smad3 and restrains TGF-beta-mediated Smad signaling XREF_BIBR - XREF_BIBR."
25464508
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"SMAD7 inhibits activation of SMAD2 and SMAD3 and we show that the levels of these active SMAD proteins are decreased in cells expressing shRNA against MTA1."
22841502
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"This has been related to the facilitated Smad7 expression, which in turn acts to negatively regulates Smad3 and its fibrotic action (Afrakhte et al., 1998; Ebisawa et al., 2001; Kavsak et al., 2000)."
28886988
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"In line with the hypothesis that Smad2/3 signaling is responsible for the induction of SBE containing promoters by DeltaNp73, Smad7 which inhibits Smad2 and Smad3 activation XREF_BIBR, already at a very low concentration effectively prevented the DeltaNp73 stimulated increase in TGF-beta signaling in Hep3B cells (XREF_FIG)."
23236396
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"SMAD7 can block the activation of SMAD2 and SMAD3, while the SMAD anchor for receptor activation (SARA, also known as ZFYVE9) stabilizes the SMAD4-TGFBR1 interaction."
22539603
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"We previously found that although exogenous Smad7 strongly repressed Smad3 activation by TGFβ, the inhibition of muscle differentiation by TGFβ was not rescued by exogenous expression of Smad7 [11]."
32033454
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"In vivo, deletion of Smad7 enhanced Smad3 signaling, thereby promoting miR-192 expression and fibrosis in obstructive kidney disease."
21927575
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"Briefly, smad3 has been proven to play a pivotal pathogenic role; while smad7, as an inhibitory member of the smad superfamily, antagonizes the action of smad3 XREF_BIBR XREF_BIBR."
28045076
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"The present finding that disrupted Smad7 enhanced Smad3 mediated renal fibrosis added a new evidence for a protective role of Smad7 in ANG II mediated hypertensive nephropathy."
23301086
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"First, Smad7, an inhibitory Smad, reversed the inhibitory effect of myostatin but not TGFβ on myogenesis even though Smad7 potently inhibits Smad3 activation induced by both myostatin and TGFβ [11]."
32033454
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"Therefore, inhibition of Smad3 by overexpression of Smad7 dramatically reduced fibrotic responses of the kidney, lung and liver in animal models, indicating an important anti-fibrotic effect of Smad7 by antagonizing TGF-β/Smad3 signaling pathway [61–64]."
19352540
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"While transfection with siRNA to reduce Smad3 levels reversed SMC proliferation stimulated by AdSmad3 XREF_BIBR, adenoviral expression of Smad7, which blocks Smad3 signaling, effectively inhibited intimal hyperplasia XREF_BIBR."
24718260
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"Consistently, silencing of Smad7 with a specific antisense oligonucleotide restores transforming growth factor-beta1 and Smad3 signalling, thereby leading to inhibition of inflammatory cytokine production and attenuation of experimental colitis in mice."
23287011
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"Hypoxic ECs and SMCs have decreased expression of the inhibitory factor SMAD7, upregulation of TGFbeta1, increased SMAD3 activation, and ultimately upregulation of the focal adhesion molecule TGFbeta1i1."
26838310
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"Interestingly, in inflammatory bowel disease, silencing of SMAD7 with anti-sense oligonucleotide treatment restored SMAD3 activation and reduced synthesis of inflammatory cytokines by endogenous TGFbeta [XREF_BIBR]."
27473228
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"Interestingly, the elevated expression of smad7, which inhibits p-Smad3, was increased following BCA treatment."
| PMC
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"In in vivo, deletion of Smad7 enhanced Smad3 signaling, thereby promoting miR-192 expression and fibrosis in obstructive kidney disease."
26889404
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"Alternatively, Smad7 is an inhibitory Smad and negatively regulates Smad3 activation by its negative feedback mechanism."
26997760