IndraLab

Statements

Mebendazole decreases the amount of USP5. 8 / 8
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"Notably, we found that USP5 mRNA expression was also decreased by mebendazole, suggesting that mebendazole might suppress USP5 transcription."
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"The mechanistic investigation showed that mebendazole not only prevents the interaction between USP5 and c-Maf but also suppresses USP5 transcription, thus inducing c-Maf proteasomal degradation."
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"Notably, we found that USP5 mRNA expression was also decreased by mebendazole, suggesting that mebendazole might suppress USP5 transcription.Because c-Maf turnover is processed via the proteasome, we sought to determine whether mebendazole induced c-Maf Fig. 2 Mebendazole inhibits USP5 expression and induces c-Maf degradation via the ubiquitin-proteasome pathway."
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"The results showed that mebendazole downregulated the protein expression of both USP5 and c-Maf in both LP1 and RPMI-8226 cells."
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"Mebendazole downregulated USP5 expression and disrupted the interaction between USP5 and c-Maf, thus leading to increased levels of c-Maf ubiquitination and subsequent c-Maf degradation."
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"In the above studies, mebendazole was demonstrated to downregulate USP5 expression and disrupt the interaction between USP5 and c-Maf."
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"The mechanistic investigation showed that mebendazole not only prevents the interaction between USP5 and c-Maf but also suppresses USP5 transcription, thus inducing c-Maf proteasomal degradation.Notably, mebendazole is cytotoxic to various cancer cells, including MM and leukemia cells, at higher concentrations (data not shown); however, it elicits selective anti-MM activity at low concentrations."
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"The results showed that mebendazole downregulated the protein expression of both USP5 Fig. 1 Identification of mebendazole as a promoter of c-Maf protein degradation."
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