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AKT decreases the amount of TSC2. 3 / 14
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"Furthermore, Akt mediated MDM2 (murine double minute-2) phosphorylation enables p53 sequestration and ubiquitination, consequently reducing the expression of TSC2, IGF binding protein-3 (prevents IGF binding to IGF-IR) and PTEN [phosphatase and tensin homolog; dephosphorylates PIP 3 (phosphatidylinositol 3,4,5-triphosphate)] [XREF_BIBR]."
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"As shown in Fig. 12 C, AKT -inhibitor significantly decreased the protein levels of p-AKT / AKT, p-mTOR / mTOR, BCL2, PSMD9, p-CDK1, CDK1, p-CCNB1 and CCNB1 in EECs, and increased TSC2, BAX and Caspas[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
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"In human HeLa cells, Dan et al. [36] report that while expression of constitutively active Akt had no effect on the stability of the hamartin and tuberin complex, Akt markedly decreased levels of both[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
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