IndraLab

Statements


VCL inhibits KCNMA1. 2 / 2
| 2

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"We thus expect that the use of a -100 mV holding potential during voltage clamp recordings will reduce [Ca] i and the available KCa1.1 current."

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"Neutralization of the last lysine residue (K304) in this cluster also reduced gamma3 's modulatory effect on the BK channel V 1/2 by nearly 30 mV (V 1/2 = 144 +/- 2 mV with gamma3 K304N mutant vs. 115 +/- 2 mV with wild type) (XREF_FIG)."