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CACNA1A activates calcium(2+). 31 / 31
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sparser
"Their study about the functional consequences of ΔF1502 on Ca V 2.1 channel function in Xenopus oocytes using Ba 2+ as the charge carrier (instead of the physiological permeant ion Ca 2+ ), revealed: 1) an ~ 11 mV hyperpolarizing shift in Ca V 2.1 voltage-dependent activation, 2) a 30% decrease in Ba 2+ current density at high depolarizing voltages, 3) a shift in the voltage dependence of steady-state inactivation to hyperpolarizing voltages by ~ 14 mV, and 4) a slightly slower recovery from channel inactivation."
reach
"Together, this pattern of severely altered neuronal responses to physiological stimuli suggests that HPCA deficiency might inhibit voltage-dependent Ca channels or, alternatively, modify the mechanism of maintaining the membrane potential and thus affect cellular response to membrane depolarization.In summary, we have presented evidence to support biallelic mutations in HPCA as a cause of AR primary isolated dystonia."
sparser
"Thus, 2,50-di(tertbutyl)-1,4,-benzohydroquinone (BHQ), a synthetic phenolic compound that inhibits sarcoendoplasmic Ca 2+ ATPases (SERCAs) and with pro-oxidant properties, can also inhibit Ca V 2.1 voltage-dependent activation to ameliorate gating defects in the channel and subsequently prevent synaptic transmission problems produced by the S218L CACNA1A mutation causing a severe form of FHM with slowly progressive cerebellar ataxia and atrophy in humans [ xref ]."
sparser
"To directly verify that the documented hyperpolarizing shift in the steady-state voltage-dependent activation of Ca v 1.3 compared to Ca v 1.2 L-type Ca 2+ channel contributes importantly to the observed decrease in the AV node firing frequency in the null mutant mice, we generated computer modeling to directly assess the effect of Ca v 1.2 and Ca v 1.3 currents on the properties and characteristics of spontaneous APs of mouse AV node cells."