IndraLab

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USP9X inhibits cell differentiation. 3 / 3
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"Recently, we have shown that Msi2 is required for the self-renewal and pluripotency of mouse ESC XREF_BIBR and, more recently, we have determined that knockdown of Usp9x in mouse ESC substantially increases the differentiation of ESC (unpublished results)."
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"Immunoblot analysis failed to detect any change in the level of the astrocytic marker GFAP or neuronal marker betaIII-tubulin, indicating that loss of USP9X did not induce the differentiation of ReNcell VM cells to post-mitotic cell fates."
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"As expected, Usp9x DeltaG colonic ulcers after acute colitis were marked by increased proliferation and decreased secretory differentiation, most likely because the normalization of c-Myc and NICD1 protein is delayed in the absence of Usp9x, and the damaged intestine was locked in a proliferative state (XREF_FIG)."
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