IndraLab

Statements

TIFAB binds USP15. 15 / 15
| 5 10
sparser
"Deregulation of the TIFAB-USP15 complex, as observed in MDS-del(5q), modulates p53 activity and has critical functional consequences for HSCs under stress conditions [ xref ]."
41440765
reach
"Mass spectrometry analysis confirmed that TIFAB binds endogenous TRAF6 in a human del(5q) AML cell line, but these studies also revealed that TIFAB readily binds the ubiquitin-specific peptidase USP15[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
32910997
sparser
"In addition to regulating TRAF6, TIFAB also directly binds USP15."
37102608
reach
"In addition to regulating TRAF6, TIFAB also directly binds USP15."
37102608
sparser
"One of the key substrates regulated by the TIFAB-USP15 axis includes p53. xref Deletion of TIFAB sensitizes hematopoietic cells to a variety of cellular stressors, which are dependent on p53 activation. xref Gene set enrichment analysis (GSEA) revealed that a p53-related gene signature was positively enriched inTifab -/- ;miR-146a -/- LSK cells treated with LPS compared to vehicle-treatedTifab -/- ;miR-146a -/- cells, while there was no significant enrichment of a p53-related signature in WT cells treated with LPS ( xref )."
37102608
sparser
"A number of these TIFAB-interacting proteins appeared to function in ubiquitin-dependent regulatory pathways, partly explained by the interaction of TIFAB with USP15."
32910997
reach
"A series of biochemical assays and co-immunoprecipitation experiments confirmed that TIFAB binds USP15, and this appears to be partly dependent on the deubiquitinating (DUB) activity of USP15."
32910997
reach
"Moreover, TIFAB likely binds the C-terminal hydrolase domain of USP15, thus placing the binding of TIFAB near the DUB active site."
32910997
sparser
"TIFAB forms a complex with USP15, increasing the rate of USP15 deubiquitination and regulating p53 signaling in malignant hematopoietic cells [ xref ]."
32354135
sparser
"A series of biochemical assays and co-immunoprecipitation experiments confirmed that TIFAB binds USP15, and this appears to be partly dependent on the deubiquitinating (DUB) activity of USP15."
32910997
sparser
"Mass spectrometry analysis confirmed that TIFAB binds endogenous TRAF6 in a human del(5q) AML cell line, but these studies also revealed that TIFAB readily binds the ubiquitin-specific peptidase USP15[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
32910997
sparser
"Niederkorn and colleagues suggested that the dysregulation of the TIFAB-USP15 complex, as seen in conditions like del(5q) myelodysplasia or MLL-rearranged leukemia, through the deubiquitination of MDM2 and KEAP1, may lead to a reduction in p53 expression."
39048945
sparser
"TIFAB binds to the catalytic domain of USP15 resulting in improved activities such as deubiquitination of MDM2 (a Ub E3 ligase of p53) [ xref ]."
35008940
sparser
"Our previous study in hematopoietic cells uncovered a TIFAB-USP15 complex that affects p53 signaling and cellular stress responses [ xref , xref ], indicating that USP15 might have several important roles in leukemic progenitors."
34465865
reach
"Niederkorn and colleagues suggested that the dysregulation of the TIFAB-USP15 complex, as seen in conditions like del(5q) myelodysplasia or MLL-rearranged leukemia, through the deubiquitination of MDM2 and KEAP1, may lead to a reduction in p53 expression."
39048945