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EGF increases the amount of EGF. 55 / 62
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"More recently, Choi et al. [ 13 ] showed that the effects of EGF on goat oocyte maturation can be potentiated by progesterone, since this hormone increases the expression of EGF-like factors that infl[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
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"Indeed, EGF levels in the brain were increased by EGF treatment, however to a lesser extent than in the plasma."
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"Moreover, A431 cells express a high level of epidermal growth factor receptors (EGFRs) activated by EGF, a nonheparin binding growth factor, which does not interact with CMDB7 (Bagheri-Yarmand et al, 1998b)."
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"Epidermal growth factor (EGF) is synthesized in the pancreas and diabetic animals have low levels of EGF."
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"Our study validated that EGF‐encoding cmRNA, when introduced in vitro, led to effective EGF expression in HaCaT and NHDF cells."
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"Because the damaged basement membrane induces the expression of epidermal growth factor (EGF) in the midgut, which activates the EGFR pathways in the midgut progenitor cells."
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"EGF promoter polymorphisms are observed to modulate EGF levels and thought to have effect on susceptibility to various carcinomas but the results are inconsistent."
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"Overexpression of the HSP70 gene had no effect on the accumulation of EGF in the offspring whereas EGF knockout significantly decreased the EGF level."
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"Of interest, phenantroline inhibited EGF-mediated effects such as EGFR phosphorylation, H 2 O 2 production and CD11b upregulation indicating the presence of an autocrine loop mediated by EGFR-activate[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
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"Preliminary studies confirmed that sialoadenectomy reduced circulating EGF levels in nude mice (from 0.17 +/- 0.02 to 0.09 +/- 0.02 ng/ml), and that ip injection of 5 micrograms EGF raised EGF levels (the peak level of 91.7 +/- 3.3 ng/ml was achieved at 30 min, with a subsequent half-life of about 1 h)."
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"The results demonstrated that the expressions of PI3K, EGF and the phosphorylation level of Akt in HSCs grown on high-stiffness substrate were all obviously higher than those in HSCs grown on low-stif[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
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"In the liver, EGF is upregulated in a rat model of liver fibrogenesis and in human cirrhotic liver tissues (7, 8), and a polymorphism in the human EGF gene that leads to increased EGF expression is associated with increased fibrosis and cirrhosis progression in patients with chronic hepatitis C (9)."
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"However, this same EGF treatment failed to restore mucosal Egf mRNA expression in TPN treated mice (XREF_FIG B)."
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"Infusion of EGF from alzet minipumps raised circulating EGF levels, however, A431 tumor growth was not significantly changed."
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"Consequently, the development of the dermal structure within the EGF@Silnanom SPB group surpassed that of the untreated group during the later stages of the healing process.Furthermore, the results de[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
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"We observed that EGF treatment induced expression of Egf and Egfr in GCs."
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"Polymorphisms in the EGF gene modulate EGF levels."
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"Infusion of EGF from Alzet minipumps raised circulating EGF levels."
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"Mechanisms by which the EGF gene polymorphism modulates EGF levels and associations among EGF gene polymorphism, EGF levels, and hepatocellular carcinoma."
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"Subsequent topical application of EGF restored normal wound healing.2 O'Daniel et al. have shown expression of EGF receptors on the tympanic membrane in the cat."
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"Furthermore, the area of EGF receptor positive cells in the wound surface of the EGF nanogroup was higher than that of the EGF group, with the results demonstrating that EGF nanoparticles upregulated the expression of EGF receptors in wound surface cells, promoted wound surface healing, and had better efficacy than EGF."
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"Presence of EGF +61 A> G polymorphism in Brazilian subjects was associated with glioma risk and increased circulating EGF levels."
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"The immunofluorescence staining of EGF in mice corneal epithelium showed that the immunofluorescence luminance of EGF in diabetic group were weaker than normal group and netrin-1 treatment can effectively increase the expression of EGF in diabetic mice."
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"In conjunction with this, molecules that enhance the gene expression of IL-1alpha epidermal growth factor (EGF) and transforming growth factor-beta1 (TGF-beta1) were also shown to enhance the expression of IL-1RI, but IL-1alpha did not increase the gene expression of IL-1RI."
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"This effect may be explained by a Ticagrelor-induced decrease in serum levels of the epidermal growth factor (EGF), the latter playing a major role in the genesis of endothelial dysfunction including atherosclerosis and vessel remodeling [35]."
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"Thus, it can be suggested that EGF G/G homozygotes producing high levels of EGF may have aberrant glutamatergic neurotransmission, which sensitizes them to the development of schizophrenic psychosis.W[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
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"EGF expression is associated with progression of cirrhosis,13 and in animal models, overexpression of EGF in liver tissue leads to formation of HCC.33 34 In humans, a functional single nucleotide polymorphism in the EGF gene increases EGF levels in liver tissue, and this single nucleotide polymorphism is also associated with increased risk for HCC.14 Among cirrhotic patients, those with high EGF expression in their liver tissue have the poorest overall survival."
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"EGF promoter polymorphisms can modulate EGF levels, thus affect the susceptibility to many cancers and EGF G-1380A was reported to be marginally associated with cancer susceptibility ( Xu et al., 2010[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
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"EGF and Notch null mutations are recessive, thatis, a half-dosage is sufficient for patterning (+/-labels); this and an EGF overexpression line with known EGF levels (JU1107 label; see XREF_TABLE for a list of the experimental lines referred in this study) delimit the central wild-type region."
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"The generation of mature EGF involves pro EGF gene transcription, translation of pro EGF mRNA to synthesize the EGF precursor and the posttranstational process of pro EGF to release mature EGF (2)."
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"A SNP is found in the EGF gene 61G> A, which leads to upregulated EGF levels for the transcriptionally more active G allele."
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"Epidermal growth factor and insulin like growth factor I upregulate the expression of the epidermal growth factor system in rat liver."
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"EGF administration increased levels of crypt proliferation, as alcohol+ EGF mice had higher levels of S-phase cells than alcohol mice; however, EGF was unable to restore crypt proliferation in alcohol+ EGF levels to levels seen in water mice."
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"The expression of EGF in mice [28] and EGF receptor in rats [29] are stimulated by estrogens.Elevated EGF precursor mRNA expression on D 30 and the drop in expression on D 40 of pregnancy are correlat[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
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"In the treatment group, endogenous EGF mRNA was significantly higher than in the control group, which indicated that exogenous EGF treatment accelerated the healing of diabetic wounds by upregulating the expression of EGF mRNA in newly-generated tissues."
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"In contrast, intestinal EGF levels increased following CLP, and were further augmented by exogenous EGF treatment."
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"The addition of exogenous EGF treatment after the onset of sepsis did not increase serum levels of EGF (30.4 pg/ml +/- 10.2), with animals having similar systemic levels to untreated septic mice (XREF_FIG, n = 12/group)."
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"ARPKD has been linked to elevations in the expression of epidermal growth factor (EGF), epidermal growth factor receptor (EGFR), or transforming growth factor-α (TGF-α) levels [35]."
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"In conclusion, EGF may accelerate the healing of DFU, and exogenous EGF treatment may upregulate the expression of EGF mRNA in newly generated tissues."
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"The addition of exogenous EGF treatment after the onset of sepsis further augmented intestinal EGF mRNA levels to 2.5 times greater than sham mice (XREF_FIG)."
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"As shown by Western blotting, EGF + HGF downregulated E-cadherin protein expression while upregulating the protein expression of EGF, HGF, EGFR, and EMT marker proteins and the related transcription factors N-cadherin, vimentin, snail-1, slug, ZEB, and Twist in A549 cells."
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"These results indicate that the Ras-ERK and Ras-Rac-JNK signaling pathways are essential for the EGF-induced expression of 12( S )-lipoxygenase, and the Ras-ERK pathway plays a more significant role t[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
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"Animals fed the EGF deficient diet RMS had markedly increased EGF and TGF-alpha mRNA levels in duodenum and ileum compared with dam fed controls and significantly elevated total intestinal content of TGF-alpha peptide."
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"Polymorphisms in the EGF gene modulate EGF levels."
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"Exogenous EGF treatment increases EGF mRNA expression."
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"This may demonstrate that exogenous EGF promotes the expression of endogenous EGF, which upregulates partial EGF gene expression (52,53)."
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"EGF Treatment Upregulates EGF Expression in MED Rats."
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"The STAT dimers translocate to the nucleus, bind response elements and activate transcription of genes.JAK, Janus kinase; P, phosphate; STAT, signal transducer and activator of transcription.ceptors for epidermal growth factor (EGF), platelet derived growth factor (PDGF) and colony stimulating factor 1 (CSF-l)] phosphorylate members of the STAT family."
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"EGF given i.d. did not affect gastric or pancreatic secretion and failed to raise significantly plasma EGF level."
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"XREF_BIBR, XREF_BIBR The ligands that activate EGFR, especially EGF, therefore increase HCV cellular entry, XREF_BIBR and the EGF SNP is known to increase liver EGF levels."
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"The expression of EGF was significantly upregulated in the PRP gel group as compared to the SP and diabetic control groups, demonstrating that the exogenous proteins released from the PRP gel improved the expression of EGF in newly formed skin tissue."
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"For instance, macrophages seeded within a cancer cell spheroid, but not those embedded around the spheroid, upregulate expression of epidermal growth factor (EGF) enhancing spheroid growth and chemore[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
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"Surprisingly, we also found that the amount of EGF mRNA is increased in old cells and that EGF modulates the expression of both EGF and EGF-receptor mRNAs."
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"These results indicate that LTC4 mediated CysLT1 signaling may regulate the EGF induced second wave of Rac1 activation.As described above, Tiam1 is responsible for the EGF induced second wave of Rac1 activation, and EGF increases Tiam1 expression in terms of both mRNA and protein levels."
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"However, the mRNA level of EGF showed no significant difference among groups ( Fig. 5 B), which suggested that KLK8 might induce EGF release by cleavage of the pro-EGF."
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