IndraLab

Statements

CYLD binds MYC. 4 / 4
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"To confirm our MS findings, we transfected 293T cells with Myc—Cyld and Flag—NLRP6 expression constructs."
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"Anti-Myc immunoprecipitated Flag—NLRP6 and anti-Flag immunoprecipitated Myc—Cyld, suggesting that Cyld and NLRP6 physically interact ( xref )."
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"To test whether Cyld cleaves K48- or K63-linked ubiquitination, we coexpressed Flag—NLRP6, Myc—Cyld and HA—UbK48 (in which all of the lysine residues within Ub except K48 were mutated to arginine) or HA—UbK63 (in which all of the lysine residues within Ub except K63 were mutated to arginine)."
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"To investigate whether Cyld regulates NLRP6 via deubiquitination, we transfected 293T cells with Flag—NLRP6, Myc—Cyld and hemagglutinin (HA)—Ub."
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