IndraLab

Statements

MTORC1 binds CYLD. 2 / 2
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"The adverse phenotypes observed in 2-week TAC-CR-CYLD mice were reminiscent of those in CR-mTOR KO mice, including inhibited p-p70S6K, accumulated autophagic vacuoles with undegraded contents, cardiomyocyte death, and cardiac dysfunction [ xref ], supporting the axis of CYLD–mTORC1 inactivation–autolysosome efflux inhibition–cardiomyocyte death in PO-hearts."
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reach
"Thus, except aforementioned K63 deubiquitination of mTOR and Rab7, the potential of TRIM28 or TRIMP37 and CYLD interaction in mTORC1 reactivation and suppressing autolysosome efflux in the heart deserves further investigation."
32553594