IndraLab

Statements

USP47 inhibits TP53. 6 / 6
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"Compound 1, a selective inhibitor of USP7 and USP47 with moderate potency, demonstrates inhibition of USP7 in cells and induces elevated p53 and apoptosis in cancer cell lines."
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"A class of dual small molecule inhibitors of USP7 and USP47 has been identified to promote p53 activity and apoptosis in MM and B-cell leukemia cells in vitro and xenograft models."
33643919
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"Finally , we provide evidence that USP47 has oncogenic potential , and depletion of USP47 induces p53 by regulation of RPS2 and , therefore , inhibits cell proliferation , colony formation , and tumor progression in cancer cell lines and a mouse xenograft model in a p53-dependent manner ."
32370049
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"Finally , we show that depletion of USP47 induces p53 and therefore inhibits cell proliferation , colony formation , and tumor progression in cancer cell lines and a mouse xenograft model ."
32370049
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"Notably, selective dual inhibitors of USP7 and USP47 have been synthesized and induced accumulation of p53 and apoptosis in human cancer cell lines [XREF_BIBR]."
25481052
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"As shown in Figure 2a , the depletion of USP47 increased the p53 level but not in the presence of MG132 ."
32370049