IndraLab

Statements

CACNA1A inhibits sodium(1+). 8 / 8
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"LTG preferentially inhibits neuronal hyperexcitability and modifies synaptic plasticity via use- and voltage-dependent inhibition of neuronal voltage-activated Na+ channels and possibly high-voltage-activated Ca>cf6>2+>cf1> channels."
9778599
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"Voltage-dependent inactivation of fast Na+ channels during depolarization (reduction in MDP) by the Ca2+ channel blockers explains their inhibitory effect on +Vmax and indicates that L-type Ca2+ channels had no significant role in the upstroke."
8876052
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"In companion "whole-cell" voltage-clamp experiments on canine B cells, the underlying Na+ current displays steep voltage-dependent activation and inactivation over the range of -50 to -40 mV."
2167377
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"In this study, we have made patch-clamp recordings from cultured HPP myotubes and found a defect in the normal voltage-dependent inactivation of Na+ channels."
1849724
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"Plateau potentials with a low threshold were also Na+ dependent, but these long-lasting potentials are probably produced by activation of a voltage-dependent non-inactivating Na+ conductance."
2425083
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"Ragsdale, D.S., T. Scheuer and W.A. Catterall, 1991, Frequency and voltage-dependent inhibition of Type IIA Na+ channels, expressed in a mammalian cell line, by local anesthetic, antiarrhythmic and an[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
8440304
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"The action potentials and the subthreshold spikelets were shown to be Na+ dependent and are presumably generated by a voltage-dependent inactivating Na+ conductance."
2425083
sparser
"Voltage-dependent inactivation of Na+ channels is a consequence of voltage-dependent activation, and an inactivated Na+ channel enters a non-conducting and non-transmitting signals state, as the inactivation gate, the cytoplasmic loop linking domains III and IV of the α subunit, obstructs the open pore [ xref ]."
26747084