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USP14 activates proteasome substrates. 1 / 1
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eidos
"We also tested the effect of USP14 inhibition on proteome stability using the specific inhibitor IU1-47 ( Boselli et al ., 2017 ) alone or in combination with XL-188 , since USP14 inactivation promotes degradation of some proteasome substrates in vitro and in human cells ( Lee et al ., 2010 ) ."