IndraLab

Statements

EGF activates SRC. 10 / 12
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"We show that src family kinase activity is also activated by addition of EGF to PC12 cells, which endogenously express relatively high levels of EGF receptor."
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"In this report, we demonstrate EGF dependent activation of src family tyrosine kinases in NIH3T3 cells overexpressing the human EGF receptor."
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"Because altered keratinocyte differentiation and hyperproliferation are associated with increased epidermal growth factor (EGF) receptor activity, and because SFKs are directly activated by EGF in human keratinocytes, stimulation of EGF receptor is believed to activate SFKs in psoriasis [ xref ]."
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"EGF, PDGF, and bFGF activate the SFK, cSrc in murine fibroblasts [XREF_BIBR], and in skeletal muscle cells insulin stimulates SFK activation [XREF_BIBR]."
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"Upon SFK activation induced by epidermal growth factor stimulation, fluorescent resonance energy transfer (FRET) response was detected transiently at membrane ruffles in COS1 cells co-expressing CFP-Csk and Cbp-YFP and in cells expressing a single-molecule FRET indicator consisting of CskSH2 and Cbp."
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"Subsequent studies have shown that EGF-dependent activation of SFKs led to tyrosine phosphorylation of clathrin and dynamin [4,5] ."
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"For example, the EGF-dependent activation of Src family tyrosine kinases has been observed in NIH3T3 and A431 cells [30]."
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"Taken together, those data suggest that CIN85 is Tyr phosphorylated upon EGF stimulation in a src dependent manner."
22833562
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"To test whether EGF induced src activation might induce CIN85 phosphorylation in SYF cells, we expressed wt src kinase in these cells and assessed CIN85 phosphorylation with or without EGF addition."
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"Epidermal growth factor induced stimulation of SFK activity in OV2008 cells increased PKG-Ialpha kinase activity (indicated by Ser (239) phosphorylation of the PKG substrate vasodilator stimulated phosphoprotein), which was blocked by both SKI-1 and SU6656."
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