IndraLab

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NMDAR activates KCNMA1. 4 / 4
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"A synthesized peptide of the BKalpha S0-S1 loop region, when loaded intracellularly via recording pipette, abolished the NMDAR mediated BK channel activation and effect on synaptic transmission."
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"Disruption of the BK-NMDAR interaction using a specific competing peptide mimicking BKα intracellular region prevents NMDAR-induced BK channel activation and increased glutamate synapse transmission (Zhang et al., 2018)."
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"NMDAR-induced BK channel activation has been observed at the extrasynaptic sites of olfactory bulb granule cells ( xref ) and dentate gyrus granule cells ( xref )."
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"By patch-clamp recording on mouse brain slices, we observed BK channel activation by NMDAR mediated Ca 2+ influx in dentate gyrus granule cells."
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