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USP4 activates interleukin-4 secretion. 1 / 1
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"In the study of rheumatic heart disease , Guo et al. revealed that USP4 positively modulated IL-4 secretion by T helper type 2 cells through deubiquitinating and stabilizing IRF4 which is usually the reason of allergic immune responses diseases , such as rheumatic heart disease [ 62 ] ."