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IndraLab

Statements

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phosphosite cbn pc11 biopax bel_lc signor biogrid tas lincs_drug hprd trrust | geneways tees isi trips rlimsp medscan sparser reach
reading

TP53 binds MDM2 and ARF. 5 / 5
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sparser
"ARF binds MDM2, preventing it from interacting with p53 [ xref ]."
sparser
"The function of MDM2 is in turn regulated by p19 ARF ; p19 ARF binds MDM2 to prevent degradation of p53, and thus promotes p53-dependent apoptosis [31,46] ."
sparser
"Several groups ( Kamijo et al. 1998; Pomerantz et al. 1998; Stott et al. 1998; Zhang et al. 1998 ) have found that ARF binds to MDM2 and that trimeric complexes between p53, MDM2, and ARF can form in [MISSING/INVALID API KEY: limited to 200 char for Elsevier]"
sparser
"A number of studies have revealed direct physical interactions between ARF, p53, and MDM2."
sparser
"ARF, a tumor suppressor, binds to MDM2 and promotes rapid degradation of MDM2, resulting in p53 stabilization and accumulation [ xref ]."