IndraLab

Statements

TP53 binds MDM2 and ARF. 6 / 6
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"Several groups ( Kamijo et al. 1998; Pomerantz et al. 1998; Stott et al. 1998; Zhang et al. 1998 ) have found that ARF binds to MDM2 and that trimeric complexes between p53, MDM2, and ARF can form in [MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
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"Thus, NPM seems to be a promising target in cell sensitization for chemo or radiotherapies ( xref ), especially because it impacts on the functional regulation of the axis formed by p53, HDM2, and ARF protein ( xref , xref ; xref )."
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"A number of studies have revealed direct physical interactions between ARF, p53, and MDM2."
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"ARF, a tumor suppressor, binds to MDM2 and promotes rapid degradation of MDM2, resulting in p53 stabilization and accumulation [ xref ]."
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"The function of MDM2 is in turn regulated by p19 ARF ; p19 ARF binds MDM2 to prevent degradation of p53, and thus promotes p53-dependent apoptosis [31,46] ."
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"Furthermore, NPM1 has been shown to interact with HDM2, p53, and ARF, and can exert either a positive or negative influence on cellular growth by regulating the activities of these proteins (Tollini et al., 2011; Box et al., 2016)."
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