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Statements

TP53 binds ARF and MDM2. 31 / 31
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sparser
"The nuclear bodies formed by p53, MDM2, and ARF, although variable in size, are clearly visible by light microscopy, which suggests that they likely contain a large number of additional proteins and a[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
10360174
sparser
"The observation that ARF binds to a C-terminal domain of MDM2 prompted us to test whether ARF can form a ternary complex with MDM2 and p53."
9529249
sparser
"ARF binds and inhibits MDM2 to activate p53, which has both cell cycle arrest and apoptotic functions."
20505340
sparser
"It should be emphasized, however, that overexpression of Mdm2 in some tumors lacking ARF points to more complex biochemical interactions between ARF, Mdm2, and p53 than had been previously expected."
10679383
sparser
"In cells triply transfected with plasmids expressing all three proteins, an ARF–MDM2–p53 ternary complex was formed as determined by the presence of ARF in anti-p53 immunoprecipitates (lane 18) and re[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
9529249
sparser
"Three lines of evidence support the genuineness and physiological relevance of ARF-MDM2-p53 nuclear bodies: the dependency of nuclear body formation on the integrity of ARF-MDM2-p53 triprotein interac[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
10360174
sparser
"Formation of a ternary ARF–MDM2–p53 complex suggests that if ARF regulates MDM2 function, it may not involve simple competitive disruption of MDM2's association with p53."
9529249
sparser
"It now appears that p19 ARF binds MDM2 to prevent the degradation of p53 and thus permits p53-induced apoptosis or growth arrest (see Figure 1b ) [31 •• ,32 •• ,33 • ,34 • ] ."
10072356
sparser
"However, this does not appear to be the case [87,94] , consistent with another similar scenario, such as the protection of p53 by ARF [99] , where Mdm2, p53, and ARF form a complex in which p53 is a[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
15865930
sparser
"ARF binds to the MDM2-P53 complex and prolongs the half-life of P53."
12063677
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"18, 1590–1600. [44] Kamijo, T., Weber, J.D., Zambetti, G., Zindy, F., Roussel, M.F. and Sherr, C.J. (1998) “Functional and physical interactions of the ARF tumor suppressor with p53 and mdm2”, Proc."
11908735
reach
"SUMO-1 conjugation is effected via the coordinated collaboration of Mdm2 and the tumour-suppressor ARF, which are both required in a p53, Mdm2, and ARF complex to stimulate p53 SUMOylation via SUMOylation and nucleolar targeting of Mdm2."
19522844
sparser
"A number of studies have revealed direct physical interactions between ARF, p53, and MDM2."
9778240
sparser
"Intriguingly, ARF, MDM2, and p53 can form a stable ternary complex, likely bridged by MDM2 via its two separate domains, which can independently interact with p53 and ARF ( Figure 3 )."
9529249
sparser
"Functional and physical interactions of the ARF tumor suppressor with p53 and Mdm2."
19717093
sparser
"Thus, NPM seems to be a promising target in cell sensitization for chemo or radiotherapies ( xref ), especially because it impacts on the functional regulation of the axis formed by p53, HDM2, and ARF protein ( xref , xref ; xref )."
33777934
sparser
"Functional and physical interactions of the ARF tumor suppressor with p53 and Mdm2."
12396663
sparser
"ARF binds MDM2 (murine double minute 2) and releases p53 from inhibition by MDM2, resulting in stabilization, accumulation and activation of p53."
16173922
sparser
"The function of MDM2 is in turn regulated by p19 ARF ; p19 ARF binds MDM2 to prevent degradation of p53, and thus promotes p53-dependent apoptosis [31,46] ."
12576030
sparser
"Here, we show that endogenous ARF sequentially interacts with p53 and MDM2 following irradiation of primary human and mouse embryonic fibroblasts."
15195142
sparser
"ARF, a tumor suppressor, binds to MDM2 and promotes rapid degradation of MDM2, resulting in p53 stabilization and accumulation [ xref ]."
24202322
sparser
"Complicated feedback and control mechanisms regulate ARF, Mdm2, and p53 interactions."
15467748
sparser
"In the nucleus, ARF interacts physically and functionally with Mdm2 to inhibit cell cycle progression through activation of p53."
19033735
sparser
"Thus, both the MDM2-binding activity, encoded by the exon 1β, and the nucleolus-localizing activity residing in the exon 2 domain are important for ARF, p53, and MDM2 to form nuclear bodies."
10360174
sparser
"This model, however, cannot justify the readily observed formation of ARF-MDM2-p53 ternary complex , and how p53 can be stabilized and activated even though still-abundant MDM2 is in the nucleoplasm w[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
14636574
sparser
"Another model proposes that ARF forms a ternary complex with MDM2 and p53 in the nucleoplasm, thereby blocking p53 nuclear export and stabilizing and activating p53 ."
14636574
sparser
"Functional and physical interactions of the ARF tumor suppressor with p53 and Mdm2."
19929178
sparser
"Furthermore, NPM1 has been shown to interact with HDM2, p53, and ARF, and can exert either a positive or negative influence on cellular growth by regulating the activities of these proteins ( xref ; xref )."
29940189
sparser
"ARF binds MDM2, preventing it from interacting with p53 [ xref ]."
21052502
sparser
"Because ARF binding does not compromise the ability of Mdm2 to interact with p53, both binary ARF–Mdm2 and ternary ARF–Mdm2–p53 complexes can be formed, and their roles in vivo remain a subject of s[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
10679383
sparser
"Several groups ( Kamijo et al. 1998; Pomerantz et al. 1998; Stott et al. 1998; Zhang et al. 1998 ) have found that ARF binds to MDM2 and that trimeric complexes between p53, MDM2, and ARF can form in [MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
9778240