IndraLab

Statements

TSC2 bound to TSC1 inhibits RPS6KB1. 4 / 4
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"Loss of TSC2 GAP activity or disruption of the TSC1 and TSC2 complex dysregulates S6K1 activation, which leads to abnormal cell proliferation associated with LAM disease."
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"This phosphorylation inhibits the tuberin and hamartin complex, thereby relieving its inhibition of S6K1."
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"Together, these studies imply that the tuberin and hamartin complex functions to inhibit S6K1 activation.We therefore tested if wild-type tuberin or tuberin S939A and T1462A had any effect on phosphor[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
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"Furthermore, both mouse and Drosophila genetic studies have suggested that the tuberin and hamartin complex functions to inhibit S6K1 (Kwiatkowski et al., 2002; Potter et al., 2001; Tapon et al., 2001[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
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