IndraLab
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reach
"In addition, USP18-mediated deISGylation in vitro is approximately 40-fold faster than deISGylation by the cross-reactive deubiquitinating enzymes (DUB) USP21 [15] raising the question whether deISGylation by Ub/ISG15 cross-reactive DUBs is relevant in vivo.Despite enhanced ISGylation, mice homozygous for USP18-C61A (USP18 ) are healthy and display a normal lifespan [27]."
reach
"In addition, USP18-mediated deISGylation in vitro is approximately 40-fold faster than deISGylation by the cross-reactive deubiquitinating enzymes (DUB) USP21 [15] raising the question whether deISGylation by Ub/ISG15 cross-reactive DUBs is relevant in vivo.Despite enhanced ISGylation, mice homozygous for USP18-C61A (USP18C61A/C61A) are healthy and display a normal lifespan [27]."
reach
"Moreover, USP17 is a positive regulator of RORgammat in Th17 cells, whereas USP18 has been reported to modulate T cell activation and Th17 cell differentiation by deubiquitinating of the TAK1 and TAB1 complex [XREF_BIBR] and USP25 has been regarded as a negative regulator of IL-17-mediated inflammation via TRAF5 and TRAF6 deubiquitination [XREF_BIBR]."