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USP29 activates Neoplasms. 8 / 8
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"Consistently, USP29 deletion markedly suppressed the AURKB protein abundance in all three cell lines (Supplementary Fig. 3C), arguing that this regulation exists in different types of tumors."
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"In conclusion , our study shows that elevated expression of USP29 promotes malignancy in CRC , suggesting that USP29 could be a promising target for colon cancer therapy ."
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"Taken together, these results suggest that USP29 is a bona fide DUB targeting TWIST1 protein for deubiquitination and stabilization.2.3 USP29 Promotes Tumor Progression of TNBC through Stabilizing TWIST1."
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"Consisting with the findings obtained in vitro, USP29 knockdown significantly suppressed tumor growth in vivo (Fig. 1F and G)."
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"Such tumor-promoting effects of USP29 were experimentally validated through a series of in vitro and in vivo phenotypic assays, with several lines of evidence in support of the notion that USP29 expression positively correlated with the enhanced stemness of lung adenocarcinoma cells.It is intriguing that certain labile transcription factors can be stabilized by diverse DUBs, with p53 showing a leading example."
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"Our results demonstrate USP29 promotes tumor progression in TNBC through TWIST1."
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"In our previous study, we revealed that USP29 promoted tumor cell aerobic glycolysis and glutamine anaplerosis by deubiquitinating and stabilizing the oncogenic MYC family and HIF1α, and systemic knockout of USP29 significantly suppressed tumor progression and prolonged the survival of tumor-bearing mice."
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"Systemic knockout of Usp29 depleted MYC and HIF1α in MYC-driven neuroblastoma and B cell lymphoma, inhibited critical metabolic targets and significantly prolonged survival of tumor-bearing mice."
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