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Statements

USP29 activates Neoplasms. 3 / 3
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eidos
"In conclusion , our study shows that elevated expression of USP29 promotes malignancy in CRC , suggesting that USP29 could be a promising target for colon cancer therapy ."
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"Such tumor-promoting effects of USP29 were experimentally validated through a series of in vitro and in vivo phenotypic assays, with several lines of evidence in support of the notion that USP29 expression positively correlated with the enhanced stemness of lung adenocarcinoma cells.It is intriguing that certain labile transcription factors can be stabilized by diverse DUBs, with p53 showing a leading example."
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"Systemic knockout of Usp29 depleted MYC and HIF1α in MYC-driven neuroblastoma and B cell lymphoma, inhibited critical metabolic targets and significantly prolonged survival of tumor-bearing mice."
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