IndraLab

Statements

ATXN3 binds TP53. 35 / 42
5 | 13 17
sparser
"Liu et al. found that the pathological ATX3 binds to p53 with a stronger affinity compared to wild-type ATX3."
33425926
reach
"Ataxin-3 (ATXN3), a member of the MJD DUB family, also directly binds to native and polyubiquitinated TP53 and deubiquitinates and stabilizes TP53 by repressing its degradation through the ubiquitin–proteasome pathway [44]."
36551253
sparser
"ATXN3 binds to p53, and further deubiquitinates, stabilizes p53 to regulate the functions of p53 in transactivation and apoptosis [ xref ]."
37349820
sparser
"During deubiquitination process, ATX3 mainly associates with ubiquitinated p53 through its UIMs domain."
33425926
sparser
"We observed a positive ATXN3-P53 protein correlation in HPV18 + AC, but not in HPV16 + SCC—likely due to HIF-1α-mediated suppression of P53 or HPV16 E6/E6AP-mediated P53 degradation[ xref , xref , xref ]."
41507147
sparser
"Given that HPV E6/E7 oncoproteins promote P53 degradation, they may also influence the ATXN3-P53 axis [ xref , xref , xref ]."
41507147
sparser
"Ataxin-3 (ATXN3), a member of the MJD DUB family, also directly binds to native and polyubiquitinated TP53 and deubiquitinates and stabilizes TP53 by repressing its degradation through the ubiquitin–proteasome pathway [ xref ]."
36551253
sparser
"ATX-3 binds to native and polyubiquitinated p53 and deubiquitinates and stabilizes p53 by repressing its degradation through the ubiquitin (Ub)-proteasome pathway."
27851749
biogrid
No evidence text available
27851749
biogrid
No evidence text available
27851749
biogrid
No evidence text available
27851749
biogrid
No evidence text available
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biogrid
No evidence text available
27851749
sparser
"We have found that ATX-3 interacts with p53 and functions as a novel p53 DUB."
27851749
sparser
"ATX-3 Interacts with p53."
27851749
sparser
"The interaction between ATX-3 and p53 suggested that p53 might be a substrate of ATX-3."
27851749
sparser
"As ATX-3 interacts with p53 under physiological conditions and regulates the ubiquitination of p53 in cells, it is possible that ATX-3 may regulate the turnover of p53 via the Ub-proteasome pathway."
27851749
sparser
"The interaction between ATX-3 and p53 was confirmed under physiological condition ( xref ) and with in vitro purified forms ( xref ), indicating a direct association between these two proteins."
27851749
sparser
"Consistently, as shown in xref , the cysteine 14 mutation did not affect the binding of ATX-3 to either native or ubiquitinated p53, whereas the ΔN mutant lost its binding to both forms of p53."
27851749
sparser
"Taken together, these results indicated that the binding of ATX-3 to p53 was synergistically regulated by the Josephin domain and the UIMs, with the former being primarily responsible for the binding of ATX-3 to the native p53 and further facilitating the latter to bind to ubiquitinated p53."
27851749
reach
"Ataxin-3, the machado-joseph disease deubiquitinase, interacts with p53 and functions as a novel p53 DUB [XREF_BIBR]."
29142505
sparser
"Here in our study, we discovered that ATX-3 interacts with p53 and functions as a DUB for p53."
27851749
sparser
"We have observed that the Josephin domain of ATX-3 is sufficient for the direct binding of ATX-3 to native p53, whereas the ubiquitinated p53 interacts with ATX-3 primarily through the UIMs, indicating that UIMs function to help recruit and bind the ubiquitinated p53 ( xref )."
27851749
sparser
"Therefore, both the Josephin and UIM domain coordinately regulate the interaction between ATX-3 and p53 ( xref )."
27851749
reach
"ATX-3 binds to native and polyubiquitinated p53 and deubiquitinates and stabilizes p53 by repressing its degradation through the ubiquitin (Ub)-proteasome pathway."
27851749
reach
"We have found that ATX-3 interacts with p53 and functions as a novel p53 DUB."
27851749
reach
"The interaction between ATX-3 and p53 was confirmed under physiological condition (XREF_FIG) and with in vitro purified forms (XREF_FIG), indicating a direct association between these two proteins."
27851749
reach
"Taken together, these results indicated that the binding of ATX-3 to p53 was synergistically regulated by the Josephin domain and the UIMs, with the former being primarily responsible for the binding of ATX-3 to the native p53 and further facilitating the latter to bind to ubiquitinated p53."
27851749
reach
"The interaction between ATX-3 and p53 suggested that p53 might be a substrate of ATX-3."
27851749
reach
"As ATX-3 interacts with p53 under physiological conditions and regulates the ubiquitination of p53 in cells, it is possible that ATX-3 may regulate the turnover of p53 via the Ub-proteasome pathway."
27851749
reach
"We wonder whether the polyQ expansion affects the ATX-3 and p53 interaction."
27851749
reach
"Here in our study, we discovered that ATX-3 interacts with p53 and functions as a DUB for p53."
27851749
reach
"ATXN3 binds to p53, and further deubiquitinates, stabilizes p53 to regulate the functions of p53 in transactivation and apoptosis [31]."
37349820
reach
"Therefore, both the Josephin and UIM domain coordinately regulate the interaction between ATX-3 and p53 (XREF_FIG)."
27851749
reach
"The direct interaction between ATX-3 and p53 is primarily mediated by the Josephin domain, and the first two UIM domains function to enhance the interaction by trapping the Ub-chains on p53."
27851749