IndraLab

Statements

PRMT5 methylates TP53 on R333. 5 / 5
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reach
"In particular, PRMT5 interacts with and methylates p53 at R333, R335 and R337 upon DNA damage (XREF_FIG)."
21975038
sparser
"Additionally, PRMT5 may directly methylate P53 on R333, R335 and R337, preventing its oligomerization with MDM2, which prevents TP53 binding to its target genes xref ."
36167829
sparser
"PRMT5 methylates p53 at R333, R335, and R337, resulting in changes in oligomerization, nuclear location, and DNA binding specificity. xref Moreover, DNA damage led to elevated p53 dimethylation."
34314149
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"The PRMT5 dependent methylation of p53 at residues R333, R335 and R337 represses the p53-DNA interaction."
32379587
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"PRMT5 induces arginine methylation of tumor suppressor p53 on the arginine 333,335 and 337 and affects the p53 target gene specificity, thereby escaping p53 surveillance and leading to tumorigenesis."
30713476