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Sulforaphane inhibits NLRP3. 37 / 37
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"In our results, SFN attenuated activation of NLRP3 and NLRC4 inflammasomes but not AIM2 inflammasome."
27423466
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"SFN suppressed NLRP3 inflammasome activation induced by MSU crystals, adenosine triphosphate and nigericin but not by poly (dA : dT) in primary mouse macrophages, independent of the reactive oxygen species pathway."
29340626
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"In the current study, we demonstrated that Sulforaphane (SFN), a dietary natural product, inhibits NLRP3 inflammasome mediated IL-1beta and IL-18 secretion and pyroptosis in murine microglial cells."
33711331
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"We investigated whether SFN inhibited the activation of the NLRP3 inflammasome induced by the saturated fatty acid, palmitate, in primary mouse hepatocytes."
27075683
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"Also, Yang et al. 38 showed that NLRP3 inhibition by sulforaphane, a compound derived from cruciferous vegehtables, resulted in amelioration of hepatic steatosis in high-fat fed mice 38."
28615649
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"Additionally, sulforaphane inhibited the activity of the NLRP3 inflammasome by regulating the inflammasome complex itself and the AMP-activated protein kinase-autophagy axis (Yang, Yeon, et al., 2018)."
34053242
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"For example, the ketone body, b-hydroxybutyrate, which specifically inhibits NLRP3 inflammasome activation via potassium efflux blockade, and the naturally derived antioxidant, sulforaphane, have been shown to attenuate MSU induced responses in murine models of gout."
29892292
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"PA and LPS may contribute to SI observed in obesity, while the dietary antioxidant sulforaphane has been shown to reduce activation of the NLRP3 inflammasome."
35271969
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"The results showed that sulforaphane preferentially inhibited cathepsin B- and caspase-1-dependent NLRP3 inflammasome activation induced by mostly Abeta1-42 monomers, an effect that potently reduced excessive secretion of the proinflammatory cytokine interleukin-1beta (IL-1beta)."
26827637
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"( 2 ) What are the molecular mechanisms underlying NLRP3 inhibition by sulforaphane in gout ?"
31200447
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"A few NLRP3 inflammasome inhibitors, including sulforaphane, isoliquiritigenin, beta-hydroxybutyrate (BHB), flufenamic acid, mefenamic acid, 3,4-methylenedioxy-beta-nitrostyrene (MNS), parthenolide, BAY 11-7082, INF39, and MCC950, have been developed, but there is no evidence showing that these compounds can specifically and directly inhibit NLRP3 itself."
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"Interestingly, it has been reported that SFN inhibited the activation of NLRP1, NLRP3, and NLRC4 inflammasomes [66,67]."
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"SFN inhibits NLRP3 even in KEAP1 knockout cells [ xref ]."
32053878
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"Different NLRP3 inflammasome inhibitors, including sulforaphane, β-hydroxybutyrate, glyburide, flufenamic acid, mefenamic acid, parthenolide, BAY 11-7082, INF39, and MCC950 have been developed, but there is no evidence demonstrating that these compounds directly and specifically target NLRP3 itself (212)."
30619282
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"Similarly, STZ-induced diabetic rats also had elevated retinal NLRP3 protein, which was attenuated by sulforaphane [121] and methylene blue [122] treatment."
32019187
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"SFN inhibited ligand independent activation of the NLRP3 inflammasome, suggesting that SFN may act directly on the NLRP3 inflammasome complex."
29340626
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"Oral sulforaphane reduced symptoms and inflammatory infiltrates in a mouse model of acute foot gout, attributed to inhibition of the NLRP3 inflammasome by sulforaphane (Yang, Yeon, et al., 2018)."
34053242
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"Our data revealed that NLRP3 inflammasome activation is associated with cerulein induced inflammation in acini and suppressed by SFN."
27847555
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"Sulforaphane also down-regulated the expressions of cleaved caspase-1, IL-1beta, and IL-18 and inhibited the activation of NLRP3 inflammasome."
32508671
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"Consistently, oral administration of SFN blocked MSU-crystal-induced activation of the NLRP3 inflammasome in a mouse air pouch gout model."
29340626
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"This neuroprotective effect is likely exerted by Sulforaphane inhibited NLRP3 inflammasome activation caused by the downregulation of NLRP3, the induction of cleaved caspase-1, and thus the reduction of IL-1beta and IL-18."
28189971
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"In this study, we found that sulforaphane (1-isothiocyanato-4-methylsulfinylbutane; SFN) suppressed the activation of the NLRP3 inflammasome activation induced by saturated fatty acid in hepatocytes."
27075683
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"In a peritonitis model of acute gout, SFN treatment significantly reduced MSU crystal induced IL-1beta production, demonstrating that SFN inhibits the NLRP3 inflammasome function in vivo."
27672241
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"SFN Inhibited NLRP3 Inflammasome Activation in Cerulein Stimulated Pancreatic Acinar Cells."
27847555
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"Sulforaphane treatment inhibits NLRP3 inflammasome activation and the downregulation of cleaved caspase-1, while reducing IL-1beta and IL-18 expression."
28189971
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"Sulforaphane attenuates activation of NLRP3 and NLRC4 inflammasomes but not AIM2 inflammasome."
27423466
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"SFN inhibited ligand independent activation of the NLRP3 inflammasome suggesting that SFN acts directly on the NLRP3 inflammasome complex."
33534121
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"Sulforaphane suppresses the activation of the NLRP3 inflammasome induced by saturated fatty acid in primary hepatocytes."
27075683
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"In human microglia like THP-1 cells treated with Abeta, sulforaphane suppressed the activation of NLRP3 (NLRP3 : NOD like receptor, leucine rich repeat (LRR), and pyrin domain containing 3) inflammasome [XREF_BIBR]."
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"Mechanistically, SFN reduced messenger ribonucleic acid and protein levels of TLR4, NLRP3, apoptosis-associated speck-like protein, and Caspase-1 in C2C12 cells, thereby inhibiting the inflammatory response and promoting myogenic differentiation."
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"These results demonstrate that SFN suppressed the activation of the NLRP3 inflammasome induced by saturated fatty acid in hepatocytes."
27075683
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"SFN also exerted antioxidant effects, activated the Nrf2 pathway, and inhibited the NLRP3 inflammasome in Muller cells."
30606939
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"In the current study, we demonstrated that Sulforaphane (SFN), a dietary natural product, inhibits NLRP3 inflammasome mediated IL-1beta and IL-18 secretion and pyroptosis in murine microglial cells."
33711331
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"SFN and 15d-PGJ2 inhibit activation of NLRP3 in the absence of NRF2 expression in a very fast manner, suggesting that transcriptional effects are not relevant for NLRP3 inhibition [22,141,142]."
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"However, in this area, a number of issues remain to be clarified: (1) What are the exact mechanisms through which 2ccPA and hydroxytyrosol inhibit NLRP3 activation in MS and AD, respectively? (2) What are the molecular mechanisms underlying NLRP3 inhibition by sulforaphane in gout? (3) How do some polyphenols block both canonical and non-canonical NLRP3 assembly? (4) Can phytochemicals targeting both canonical and non-canonical inflammasome activation be regarded as the most reliable pharmacological approaches for the management of CNS, metabolic, and inflammatory diseases? (5) Can a dietary supplementation with phytochemicals prevent or counteract neuroinflammatory and neurodegenerative processes, metabolic alterations, and immune/inflammatory responses? (6) Can phytochemicals exert beneficial effects in CNS, metabolic, and inflammatory diseases through the inhibition of other inflammasomes, including NRLP1, NLRP6, AIM2, and NLRC4?"
31200447
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"SFN inhibits NLRP3 even in KEAP1 knockout cells [22]."
32053878
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"In primary mouse macrophages, SFN inhibited NLRP3 inflammasome activation induced by MSU crystals, adenosine triphosphate, and nigericin independent of the reactive oxygen species pathway."
33534121