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USP10 activates protein deubiquitination. 1 / 1
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"In the case of DNA damage , the phosphorylation of USP10 at Thr42 and Ser337 mediated by ATM is essential for its translocation to the nucleus , where USP10 induces the deubiquitination of p53 and makes p53 work as a tumor suppressor ( Fig. 2c ) .122 In addition to ubiquitination , p53 can also undergo other ubiquitination-like modifications , such as neddylation and SUMOylation ."