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A database built with INDRA combining content from numerous readers and databases. This page allows you to curate the loaded statements. For more information please see the manual.

This Project

INDRA is developed by indralabs, a part of the Harvard Medical School Laboratory of Systems Pharmacology.

This project, indra_db, is also developed by the indralab team. For more information on how we procure our sources, you can go here. This work was funded by ARO grant W911NF‐15‐1‐0544 under the DARPA Communicating with Computers program.

IndraLab

Statements

USP10 activates protein deubiquitination. 1 / 1

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"In the case of DNA damage , the phosphorylation of USP10 at Thr42 and Ser337 mediated by ATM is essential for its translocation to the nucleus , where USP10 induces the deubiquitination of p53 and makes p53 work as a tumor suppressor ( Fig. 2c ) .122 In addition to ubiquitination , p53 can also undergo other ubiquitination-like modifications , such as neddylation and SUMOylation ."

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Our Sources:

INDRA allows us to combine the results from a multitude of sources. In particular, the INDRA Database draws on the following...