IndraLab

Statements

PSMD14 binds Proteasome. 3 / 8
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"WT Rpn11 in the ATPγS-bound proteasome cleaved Ub-GC-TAMRA with a k cat of 0.52 min −1 and a K M of 356 μM ( Figure 3 D; Table S1 )."
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"In the most well-known example, the three DUBs, RPN11, USP14, and UCHL5, bind to the proteasome to deubiquitinate proteins substrates destined to degradation, thus recycling the ubiquitin molecules (99)."
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"The p97 proteome also contained many proteasome subunits, but not the proteasome‐associated DUBs Rpn11/PSMD14, Ubp6/USP14 or UCH37/UCHL5 (Collins & Goldberg, 2017)."
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